Microsomal Ethanol Oxidizing System
- Microsomal Ethanol Oxidizing System
The Microsomal Ethanol Oxidizing System (MEOS) is an alternate pathway of ethanol metabolism to the oxidation of ethanol via alcohol dehydrogenase. While playing only a minor role in ethanol metabolism in average individuals, MEOS activity increases after chronic alcohol consumption. Increase in MEOS activity is correlated with an increase in cytochrome P450, particular CYP2EI, seen most conclusively in alcohol dehydrogenase negative deer mice.[ Chales S. Lieber. 2004. The Discovery of the Microsomal Ethanol Oxidizing System and Its Physiologic and Pathologic Role. "Drug Metabolism Reviews" 36:511-529. ] ]The MEOS pathway requires oxidation of NADPH to NADP, which consumes ATP and dissipates heat, thus leading to the hypothesis that long term drinkers see an increase in resting energy expenditure. [ Francisco Santolaria and Emilio González-Reimers. 2003. Alcohol and Nutrition: anIntegrated Perspective in "Nutrition and Alcohol: Linking Nutrient Interactions and Dietary Intake". p. 5 Ronald Ross Watson and Victor R. Preedy (eds). Taylor and Francis, CRC Press. ]
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MOS — • mechanism of stroke deducer; • medial orbital sulcus; • medical outcomes study; • metal oxide sensor; • microsomal ethanol oxidizing system; • mitral opening snap; • Moloney murine sarcoma; • myelofibrosis osteosclerosis … Dictionary of medical acronyms & abbreviations
