Friend virus

Friend virus

Taxobox
name = "PAGENAME"
virus_group = vi
familia = "Retroviridae"
subfamilia = "Orthoretrovirinae"
genus = "Gammaretrovirus"
species = "Murine leukemia virus"
subdivision_ranks = Serotype
subdivision = "Friend virus"The Friend virus is a strain of murine leukemia virus identified by Charlotte Friend in 1956. The virus infects adult immunocompetent mice and is a well-established model for studying genetic resistance to infection by an immunosuppressive retrovirus. The Friend virus has been used for both immunotherapy and vaccines. It is a member of the retroviridae group of viruses, with its nucleic acid being ssRNA.

Vaccination

Experiments have shown that it is possible to protect against Friend virus infection with several types of vaccines, including attenuated viruses, viral proteins, peptides, and recombinant vaccinia vectors expressing the Friend virus gene. In a study of vaccinated mice, it was possible to identify the immunological epitopes required for protection against the virus, thus determining the types of immunological responses necessary or required for protection against it. The research discovered protective epitopes that were localized to F-MuLV gag and env proteins. This was achieved using recombinant vaccinia viruses expressing the 74 and 76 genes of FV.

Implications

Friend virus models showed valuable information regarding genetic resistance to retroviral disease. A particular gene of interest is the Rfc-3 gene, which cause susceptibility to suppression of the FV specific anitbody response. The greater understanding by which the mechanisms work may aid in the development of immunotherapies and vaccines that may be applicable to human diseases.

References

[http://www.pnas.org/cgi/content/full/94/15/7811 Immunity to retroviral infection: The Friend virus model]


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  • Friend virus — frend n a strain of murine leukemia virus that causes erythroleukemia in mice called also Friend leukemia virus Friend Charlotte (1921 1987) American microbiologist. Friend served as professor and director of the center for experimental cell… …   Medical dictionary

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  • Friend murine erythroleukaemia cells — Lines of mouse erythroblasts transformed by the Friend virus, that can be induced to differentiate terminally, producing haemoglobin, by various agents such as dimethyl sulphoxide …   Dictionary of molecular biology

  • FRIEND, CHARLOTTE — (1921–1987), U.S. oncologist, microbiologist. Friend was born in New York City to parents who immigrated from Russia. She finished her undergraduate studies at Hunter College, New York, and upon graduating in 1943 she served in the U.S. Navy… …   Encyclopedia of Judaism

  • Friend leukemia virus — Friend leukemia virus. См. вирус лейкоза Френда. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Virus — A microorganism smaller than a bacteria, which cannot grow or reproduce apart from a living cell. A virus invades living cells and uses their chemical machinery to keep itself alive and to replicate itself. It may reproduce with fidelity or with… …   Medical dictionary

  • Friend spleen focus-forming virus — Defective virus found in certain strains of Friend helper virus, detected by its ability to form foci in spleens of mice, and believed to be responsible in those strains for the production of a leukaemia associated with polycythemia rather than… …   Dictionary of molecular biology

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  • Friend murine leukaemia virus — Murine leukaemia virus isolated by Charlotte Friend in 1956 whilst attempting to transmit the Erlich ascites tumour by cell free extracts. Causes an unusual erythroblastosis like leukaemia, in which anaemia is accompanied by large numbers of… …   Dictionary of molecular biology

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