Milas hydroxylation

Milas hydroxylation

The Milas hydroxylation is an organic reaction converting an alkene to a vicinal diol, and was developed by N. A. Milas in the 1930s.[1] The cis-diol is formed by reaction of alkenes with hydrogen peroxide and either ultraviolet light or a catalytic osmium, vanadium, or chromium oxide.


Milas hydroxylation.png


The reaction has been superseded in synthetic chemistry by the Upjohn dihydroxylation and later by the Sharpless asymmetric dihydroxylation.

References

  1. ^ N. A. Milas et al. J. Am. Chem. Soc. 1936, 1302. (doi:10.1021/ja01298a065)

See also


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