RU28362

RU28362 is a molecule which binds the glucocorticoid receptor (Corticoid Type II Receptor) but not the mineralocorticoid receptor (Corticoid Type I Receptor). [cite journal |author=Woolley C, Gould E, Sakai R, Spencer R, McEwen B |title=Effects of aldosterone or RU28362 treatment on adrenalectomy-induced cell death in the dentate gyrus of the adult rat |journal=Brain Res |volume=554 |issue=1-2 |pages=312–5 |year=1991 |pmid=1933312 |doi=10.1016/0006-8993(91)90207-C] [cite journal |author=Wong D, Lesage A, Siddall B, Funder J |title=Glucocorticoid regulation of phenylethanolamine N-methyltransferase "in vivo" |journal=FASEB J |volume=6 |issue=14 |pages=3310–5 |year=1992 |pmid=1426768]

This is in contrast to cortisol, which binds both receptors, though it binds Type II with greater affinity.

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