Gephyrin

Gephyrin

Gephyrin is a protein that is a component of the postsynaptic protein network of inhibitory synapses. Positive antibody staining for gephyrin at a synapse is consistent with the presence of glycine and/or GABA-A receptors. Gephyrin displaces GABA receptors from the GABARAP/P130 complex, then brings the receptors to the synapse. Once at the synapse, the protein binds to collybistin.

References

* Giesemann, "et al"., September 2003. Complex Formation between the Postsynaptic Scaffolding Protein Gephyrin, Profilin, and Mena: A Possible Link to the Microfilament System. "Journal of Neuroscience", 23(23):8330–8339
* Ehrensperger, "et al"., February 2007. Multiple association states between glycine receptors and gephyrin identified by SPT analysis. "Biophysical Journal", doi:10.1529/biophysj.106.095596


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