CGS21680

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ImageFile=CGS21680.pngImageSize=200px
IUPACName=3- [4- [2- [ [6-amino-9- [(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl] purin-2-yl] amino] ethyl] phenyl] propanoic acid
OtherNames=CGS 21680
Section1= Chembox Identifiers
CASNo=120225-54-9
PubChem=3086599
SMILES= CCNC(=O) [C@@H] 1 [C@H] ( [C@H] ( [C@@H] (O1)N2C=NC3=C2N=C(N=C3N)NCCC4=CC=C(C=C4)CCC(=O)O)O)O
Section2= Chembox Properties
Formula=C₂₃H₂₉N₇O₆
MolarMass=499.52
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Section3= Chembox Hazards
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CGS21680 is a specific adenosine A_2A subtype receptor agonist. It is usually presented as an organic hydrochloride salt with a molecular weight of 536.0 g/"M". It is soluble up to 3.4 mg/mL in DMSO and 20 mg/mL in 45% (w/v) "aq" 2-hydroxypropyl-β-cyclodextrin.

The chemical is currently used by researchers interested in studying neuronal transmission with a high-affinity, subtype specific analogue for adenosine. This includes research in respiration where it is believed that A_2A receptors are involved in rhythm generation in the pre-Bötzinger complex. The drug is not currently approved for use in a therapeutic capacity.

It is currently manufactured by [http://www.tocris.com/dispprod.php?ItemId=2216 Tocris] with the exclusive permission of Novartis Pharma AG, [http://www.google.com/patents?id=dBkfAAAAEBAJ&dq=4,968,697 U.S. Patent 4,968,697] .

ee also

* Adenosine receptor

References

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