Hong Kong 97 (Virus)

Hong Kong 97 (Virus)

Hong Kong 97 is a dsDNA lambdoid phage. It has a host range of E. coli and related bacteria. The capsid protein of HK97, gp5, cross-links upon maturation to form a concatenated "chain-mail" like structure [ [http://dx.doi.org/10.1016/j.jmb.2003.09.035 "The refined structure of a protein catenane"] , Journal of Molecular Biology, 12 December 2003] . The bacteriophage undergoes a maturation process upon DNA packaging during which it expands by nearly 5 nm and changes from spherically symmetrical to icosahedrally symmetrical. The assembly pathway follows gp5->pentamers and hexamers + gp4(protease) + gp3(portal) ->prohead 1->cleavage by protease->prohead 2 -> expansion and crosslinking -> head 2.

References

* [http://www.pitt.edu/~duda/HK97.html Dr. Bob Duda's Publications]
* [http://www.pitt.edu/~biohome/Dept/Frame/Faculty/hendrix.htm#Publications Dr. Roger Hendrix's Publications]


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