Differential Avidity Hypothesis
- Differential Avidity Hypothesis
The Differential Avidity Hypothesis (or simply Avidity Hypothesis) is one of two models that attempt to explain how humans have immunity despite such aggressive selection (positive and negative) to kill developing T cells during their maturation process. The other model is the Differential Signaling Hypothesis.
The Avidity hypothesis states that the affinity of the T-cell receptor for the MHC:peptide complex along with the density of the complex provide different signal strength upon binding which in terms dictate the outcome:
#strong signal leads to negative selection and thus apoptosis.
#weak signal leads to positive selection and thus rescued from apoptosis.
ee also
* T cell
* Differential Signaling Hypothesis - Another model to explain survival of T cells despite selection.
External links
* [http://microvet.arizona.edu/courses/mic419/Tutorials/Tcelldevelopment.html T cell Development]
Wikimedia Foundation.
2010.
Look at other dictionaries:
Differential avidity hypothesis — The differential avidity hypothesis (or simply avidity hypothesis) is one of two models that attempt to explain how humans have immunity despite such aggressive selection (positive and negative) to kill developing T cells during their maturation… … Wikipedia
Differential signaling hypothesis — The differential signaling hypothesis is one of two models that attempt to explain how humans have immunity despite such aggressive selection (positive and negative) to kill developing T cells during their maturation process. The other model is… … Wikipedia
Differential Signaling Hypothesis — The Differential Signaling Hypothesis is one of two models that attempt to explain how humans have immunity despite such aggressive selection (positive and negative) to kill developing T cells during their maturation process. The other model is… … Wikipedia
T cell — T cells belong to a group of white blood cells known as lymphocytes, and play a central role in cell mediated immunity. They can be distinguished from other lymphocyte types, such as B cells and natural killer cells by the presence of a special… … Wikipedia
Alzheimer's disease — Alzheimer redirects here. For other uses, see Alzheimer (disambiguation). Alzheimer s disease Classification and external resources … Wikipedia
Enfermedad de Alzheimer — Para el neurólogo que dio nombre a la enfermedad, véase Alois Alzheimer. Enfermedad de Alzheimer … Wikipedia Español
Болезнь Альцгеймера — Болезнь Альцгеймера … Википедия
Болезнь Альцхеймера — Болезнь Альцгеймера Мозг пожилого человека в норме (слева) и при патологии, вызванной болезнью Альцгеймера (справа), с указанием отличий. МКБ 10 G30., F … Википедия
Болезнь альцхаймера — Болезнь Альцгеймера Мозг пожилого человека в норме (слева) и при патологии, вызванной болезнью Альцгеймера (справа), с указанием отличий. МКБ 10 G30., F … Википедия
Пресенильный психоз — Болезнь Альцгеймера Мозг пожилого человека в норме (слева) и при патологии, вызванной болезнью Альцгеймера (справа), с указанием отличий. МКБ 10 G30., F … Википедия