- Arthur Kornberg
Infobox_Scientist
name = Arthur Kornberg
image_width =
caption = Arthur Kornberg
birth_date = birth date|1918|3|3
birth_place =New York City ,United States
death_date = death date and age|2007|10|26|1918|3|3
death_place =Stanford ,United States
residence =
citizenship =
nationality =
ethnicity =
field =
work_institutions =National Institutes of Health
Washington University Stanford University
alma_mater =University of Rochester ,New York University
doctoral_advisor =
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influences =
influenced =
prizes =Nobel Prize in Physiology or Medicine 1959
religion =
footnotes =Arthur Kornberg (
March 3 ,1918 –October 26 ,2007 ) was an Americanbiochemist who won theNobel Prize in Physiology or Medicine 1959 for his discovery of "the mechanisms in the biological synthesis ofdeoxyribonucleic acid (DNA)" together with Dr.Severo Ochoa ofNew York University . He was also awarded thePaul-Lewis Laboratories Award in Enzyme Chemistry from theAmerican Chemical Society in 1951, L.H.D. degree fromYeshiva University in 1962, as well asNational Medal of Science in 1979.His primary research interests were in
biochemistry , especiallyenzyme chemistry, the synthesis ofdeoxyribonucleic acid (DNA) and studying the nucleic acids which control heredity in animals, plants, bacteria and viruses.Early life
Born in
New York City , Arthur Kornberg was the son of Joseph and Lena Kornberg who emigrated to New York from Austrian Galicia (now part ofPoland ) in 1900 before they were married. His paternal grandfather had changed the family name from Queller (also spelled Kweller) to avoid the draft by taking on the identity of someone who had already completed military service. Joseph Kornberg married Lena Katz in 1904. He worked as a sewing machine operator in the sweat shops of the Lower East side of New York for almost 30 years, and when his health failed, opened a small hardware store inBrooklyn , where Arthur assisted customers at the age of nine. Joseph spoke at least six languages although he had no formal education.Arthur Kornberg was educated first at Abraham Lincoln High School and then at
City College inNew York City . He received at B. Sc. in 1937, followed by anM.D. at theUniversity of Rochester in 1941. Kornberg had a mildly elevated level ofbilirubin in his blood—jaundice due to anhereditary genetic condition known asGilbert's syndrome —and while at medical school he took a survey of fellow students to discover how common the condition was. The results were published in Kornberg's first research paper in 1942.His internship was at
Strong Memorial Hospital inRochester, New York , between 1941-1942. After completing his medical training he joined the armed services as a Lieutenant in theUnited States Coast Guard , serving as a ship's doctor in 1942.Rolla Dyer , the Director of National Institutes of Health, had noticed his paper and invited him to join the research team at the Nutrition Laboratory of the NIH. From 1942 to 1945, Kornberg's work was the feeding of specialized diets to rats to discover new vitamins.cientific research
The feeding of rats was boring work, and Kornberg became fascinated by
enzyme s. He transferred to Dr Severo Ochoa's laboratory atNew York University in 1946, and took summer courses atColumbia University to fill out the gaps in his knowledge of organic and physical chemistry while learning the techniques of enzyme purification at work. He became Chief of the Enzyme and Metabolism Section at NIH from 1947-1953, working on understanding of ATP production from NAD andNADP . This led to his work on how DNA is built up from simplermolecule s.In 1953 he became Professor and Head of the Department of Microbiology,
Washington University , until 1959. Here he continued experimenting with the enzymes which created DNA. In 1956 he isolated the first DNA polymerizing enzyme, now known asDNA polymerase I [Nicole Kresge, Robert D. Simoni, Robert L. Hill (2005). Arthur Kornberg's Discovery of DNA Polymerase I. J. Biol. Chem. 280, 46. [http://www.jbc.org/cgi/content/full/280/49/e46 free fulltext] ] . This won him the Nobel prize in 1959.In 1960 he received a
LL.D. again from City College, followed by aD.Sc. at theUniversity of Rochester in 1962. He became Professor and Executive Head of the Department of Biochemistry,Stanford University ,Stanford in 1959.Kornberg's mother died of gas gangrene from a
spore infection after a routinegall bladder operation in 1939. This started his lifelong fascination with spores, and he devoted some of his research efforts to understanding them while at Washington University. From 1962 to 1970, in the midst of his work on DNA synthesis, Kornberg devoted half his research effort to determining how DNA is stored in the spore, what replication mechanisms are included, and how the spore generates a new cell. This was an unfashionable but complex area of science, and although some progress was made, eventually Kornberg abandoned this research.The Arthur Kornberg Medical Research Building at the
University of Rochester Medical Center was named in his honor in 1999.Until his death Kornberg, still maintained an active research laboratory at Stanford, and regularly published peer reviewed scientific papers. For several years the focus of his research was the metabolism of
inorganic polyphosphate .The "Kornberg school" of biochemistry refers to Arthur Kornberg's many graduate students and post-doctoral fellows, i.e., his intellectual children, and the trainees of his trainees, i.e., his intellectual grandchildren. Kornberg's intellectual children include
I. Robert Lehman ,Randy Schekman ,William T. Wickner andKen-ichi Arai .Family life
On
November 21 ,1943 , Kornberg married Sylvy Ruth Levy, also a biochemist of note. She worked closely with Kornberg and contributed significantly to the discovery of DNA polymerase. The day after he was awarded the Nobel prize, she was quoted in a newspaper as saying "I was robbed".Arthur and Sylvy Kornberg had three sons: Roger David Kornberg (1947) ,
Thomas B. Kornberg (1948), and Kenneth Andrew Kornberg (1950). Roger is Professor of Structural Biology atStanford University , and the 2006 laureate of theNobel Prize in Chemistry . Thomas discoveredDNA polymerase II and III in 1970 and is now a professor at theUniversity of California, San Francisco . Kenneth is an architect specializing in the design of biomedical and biotechnology laboratories and buildings.Arthur Kornberg was married three times. His first two wives predeceased him. Sylvy Kornberg died in 1986. Arthur Kornberg remarried in 1988 but his second wife, the former Charlene Walsh Levering, died in 1995. In December 1998 Arthur Kornberg married Carolyn Dixon. She survived him.
When he was in his eighties Arthur Kornberg continued to conduct research full time at Department of Biochemistry at Stanford. He died on
October 26 ,2007 at Stanford Hospital from respiratory failure.References
* [http://www.pr-inside.com/arthur-kornberg-nobel-laureate-and-r269257.htm Arthur Kornberg, Nobel Laureate and Towering Biomedical Scientist, Dies at 89]
Books
*"For the Love of Enzymes: The Odyssey of a Biochemist". Harvard University Press, Cambridge, MA, 1989, ISBN 0-674-30776-3
*"The Golden Helix: Inside Biotech Ventures". University Science Books, 2002, ISBN 1-891389-19-XExternal links
* Kornberg's [http://nobelprize.org/nobel_prizes/medicine/laureates/1959/kornberg-bio.html Nobel Foundation biography]
* Kornberg's Nobel Lecture [http://nobelprize.org/nobel_prizes/medicine/laureates/1959/kornberg-lecture.pdf The Biologic Synthesis of Deoxyribonucleic Acid] from Nobelprize.org website
* [http://cmgm.stanford.edu/biochem/faculty/kornberg.html Stanford University page]
* [http://www.gyaszhir.hu/book.php?id=21877 Arthur Kornberg - Condolence book (Hungarian)]
* [http://www.timesonline.co.uk/tol/comment/obituaries/article2820230.ece Obituary in "The Times", 7 November 2007]
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