Wee (cell cycle)

Wee (cell cycle)

protein
Name=WEE1 homolog (S. pombe)
caption=


width=
HGNCid=12761
Symbol=WEE1
AltSymbols=
EntrezGene=7465
OMIM=193525
RefSeq=NM_003390
UniProt=P30291
PDB=
ECnumber=
Chromosome=11
Arm=p
Band=15.3-15.1
LocusSupplementaryData=
protein
Name=WEE1 homolog 2 (S. pombe)
caption=


width=
HGNCid=19684
Symbol=WEE2
AltSymbols=
EntrezGene=494551
OMIM=
RefSeq=
UniProt=
PDB=
ECnumber=
Chromosome=7
Arm=q
Band=32
LocusSupplementaryData=-q32

Wee is a protein that operates at the G2 to M-phase checkpoint. Wee becomes active if errors occur in the DNA synthesis phase. It blocks entry into mitosis until the problem is resolved. Like Rb, wee becomes inactive when hyperphosphorylated.

Its name comes from the Scottish/Irish slang word "wee", meaning "small". This is because when mutated, the cells with this mutation exhibit a smaller than usual phenotype. The protein's discoverer, Paul Nurse, was Scottish.

ee also

* cell cycle
* WEE1

External links

*


Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • Cell growth — The term cell growth is used in two different ways in biology. When used in the context of reproduction cells of living cells the phrase cell growth is shorthand for the idea of growth in cell populations by means of cell reproduction. During… …   Wikipedia

  • Cycle of the Werewolf —   First edition cover …   Wikipedia

  • Cdk1 — Cell division cycle 2, G1 to S and G2 to M, also known as Cdk1 (CDC2), is a human gene. The protein encoded by this gene is called p34cdk1 and is a cyclin dependent kinase in the Ser/Thr protein kinase family. This protein is a catalytic subunit… …   Wikipedia

  • CDK7 pathway — CDK7 is a cyclin dependent kinase shown to be not easily classified. CDK7 is both a CDK activating kinase (CAK) and a component of the general transcription factor TFIIH.IntroductionAn intricate network of cyclin dependent kinases (CDKs) are… …   Wikipedia

  • We (disambiguation) — We and similar can mean:We is the nominative case of the first person plural pronoun in the English language.We may also refer to: * Pluralis Majestatis, or the Royal We * We (novel), a novel by Yevgeny Zamyatin * We (autobiography), Charles… …   Wikipedia

  • 1.162wee — Cell cycle checkpoint genes found in Schizosaccharomyces pombe. Mutants in wee 1 and wee 2 have normal growth rate but divide earlier so cells are smaller …   Dictionary of molecular biology

  • Ciclo celular — Ciclo celular. El ciclo celular es un conjunto ordenado de sucesos que conducen al crecimiento de la célula y la división …   Wikipedia Español

  • Hyperphosphorylation — occurs when a biochemical with multiple phosphorylation sites is fully saturated. Hyperphosphorylation is one of the signalling mechanisms used by the cell to regulate mitosis. When these mechanisms fail, developmental problems or cancer are a… …   Wikipedia

  • COPS6 — COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis), also known as COPS6, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly… …   Wikipedia

  • Non-specific serine/threonine protein kinase — In enzymology, a non specific serine/threonine protein kinase (EC number|2.7.11.1) is an enzyme that catalyzes the chemical reaction:ATP + a protein ightleftharpoons ADP + a phosphoproteinThus, the two substrates of this enzyme are ATP and… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”