Entner–Doudoroff pathway

Entner–Doudoroff pathway

The Entner-Doudoroff pathway describes an alternate series of reactions that catabolize glucose to pyruvate using a set of enzymes different from those used in either glycolysis or the pentose phosphate pathway. Most bacteria use glycolysis and the pentose phosphate pathway. This pathway was firstly reported in "Journal of Biological Chemistry" in 1952 and it was discoverd by Michael Doudoroff (1911 - 1975) and Nathan Entner. [Entner, N., and Doudoroff, M. (1952) J.Biol.Chem. 196, 853 - 862]

Distinct features of the Entner-Doudoroff pathway are that it:
* Occurs only in prokaryotes.

* Uses 6-phosphogluconate dehydrase and 2-keto-3-deoxyglucosephophate aldolase to create pyruvates from glucose.

* Does not produce gases during its metabolic process, distinguishing them from microorganisms of enteric species.

* Has a net yield of 1 ATP for every glucose molecule processed, as well as 1 NADH and 1 NADPH. By comparison, glycolysis has a net yield of 2 ATP and 2 NADH for every one glucose molecule processed.

Organisms that utilize the Entner-Doudoroff pathway

There are a few bacteria that substitute classic glycolysis with the Entner-Doudoroff Pathway. They may lack enzymes essential for glycolysis, such as phosphofructokinase-1. Most organisms that use the pathway are aerobes due to the low ATP yield per glucose. [ [http://www.ias.ac.in/currsci/jul10/articles14.htm Zymomonas mobilis] ]

* "Pseudomonas aeruginosa", a Gram-negative bacteria
* "Azotobacter", a Gram-negative bacteria
* "Rhizobium", a Gram-negative bacteria
* "Enterococcus faecalis", a Gram-positive bacteria
* "Zymomonas mobilis", an "anaerobic" organism

References

Mohamed, M. Optometry Professor. Smith, K. Optometrist. Sohn, S. Biomedical Science Professor.

External links

* [http://www.dbs.umt.edu/courses/fall2006/bioc380/lectures/033/lecture.html#Section%2011.7:%20The%20Entner-Doudoroff%20Pathway Diagram at umt.edu]


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