Tafenoquine

drugbox
IUPAC_name = "N"- [2,6-dimethoxy-4-methyl-5- [3-(trifluoromethyl)
phenoxy] quinolin-8-yl] pentane-1,4-diamine

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CAS_number = 106635-80-7
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PubChem = 115358
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C = 24 | H = 28 | F = 3 | N = 3 | O = 3
molecular_weight = 463.493 g/mol
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Tafenoquine (also called WR-238605 or SB-252263) is an 8-aminoquinoline drug manufactured by GlaxoSmithKline that is currently being investigated as a potential treatment for malaria, as well as for malaria prevention.cite journal | title=A New Primaquine Analogue, Tafenoquine (WR 238605), for prophylaxis against "Plasmodium falciparum" malaria. | author=Shanks GD, Oloo AJ, Aleman GM, "et al." | journal=Clin Infect Dis | year=2001 | volume=33 | pages=1968–74 | url=http://www.journals.uchicago.edu/CID/journal/issues/v33n12/010373/010373.html | doi=10.1086/324081 | format=dead link|date=June 2008 – ^{[http://scholar.google.co.uk/scholar?hl=en&lr=&q=author%3A+intitle%3AA+New+Primaquine+Analogue%2C+Tafenoquine+%28WR+238605%29%2C+for+prophylaxis+against+%27%27Plasmodium+falciparum%27%27+malaria.&as_publication=Clin+Infect+Dis&as_ylo=2001&as_yhi=2001&btnG=Search Scholar search]} ] [cite journal | author=Lell B, Faucher JF, Missinou MA, "et al." | title=Malaria chemoprophylaxis with tafenoquine: a randomised study. | journal=Lancet | year=2000 | volume=355 | issue=9220 | pages=2041–5 | pmid=10885356 | doi=10.1016/S0140-6736(00)02352-7 ]

The main advantage of tafenoquine is that it has a long half-life and therefore does not need to be taken as frequently as primaquine. Like primaquine, tafenoquine causes haemolysis in people with G-6-PD deficiency.

The dose of tafenoquine has not been firmly established, but for the treatment of "Plasmodium vivax" malaria, a dose of 800 mg over three days has been used. [cite journal | author=Nasvelda P, Kitchener S. | title=Treatment of acute vivax malaria with tafenoquine. | journal=Trans R Soc Trop Med Hyg | volume=99 | issue=1 | year=2005 | pages=2–5 | doi=10.1016/j.trstmh.2004.01.013 ]

References