Subacute combined degeneration of spinal cord
- Subacute combined degeneration of spinal cord
Infobox_Disease
Name = PAGENAME
Caption =
DiseasesDB = 12591
ICD10 = ICD10|G|32|0|g|30, ICD10|E|53|8|e|50
ICD9 = ICD9|336.2, ICD9|266.2
ICDO =
OMIM =
MedlinePlus = 000723
eMedicineSubj =
eMedicineTopic =
MeshID = D052879
Subacute combined degeneration of spinal cord, also known as Lichtheim's disease, [WhoNamedIt|synd|492] [L. Lichtheim. Zur Kenntnis der perniciösen Anämie. Verhandlungen des Deutschen Kongress für innere Medizin, 1889, 6: 84-96. 42: 1887.] refers to degeneration of the posterior and lateral columns of the spinal cord as a result of vitamin B12 deficiency. It is usually associated with pernicious anemia.
Presentation
The pathological findings of subacute combined degeneration consist of patchy losses of myelin in the dorsal and lateral columns. Patients present with weakness of legs , arms, trunk, tingling and numbness that progressively worsens. Vision changes and change of mental state may also be present. Bilateral spastic paresis may develop and pressure, vibration and touch sense are diminished. A positive Babinski sign may be seen.
Treatment
Therapy with vitamin B12 results in partial to full recovery, depending on the duration and extent of neurodegeneration.
References
External links
* http://www.neuropathologyweb.org/chapter8/chapter8Nutritional.html
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Look at other dictionaries:
subacute combined degeneration of spinal cord — neurodegeneration involving both the posterior and lateral columns of the spinal cord, caused by vitamin B12 deficiency; a progressive disease, most often affecting persons over forty years of age, it is usually associated with pernicious anemia … Medical dictionary
subacute combined degeneration of the cord — the neurological disorder complicating a deficiency of vitamin B12 and pernicious anaemia. There is selective damage to the motor and sensory nerve fibres in the spinal cord, resulting in spasticity of the limbs and a sensory ataxia. It may also… … Medical dictionary
subacute combined degeneration of the cord — the neurological disorder complicating a deficiency of vitamin B 12 and pernicious anaemia, which causes malabsorption of the vitamin B12 by the production of intrinsic factor antibodies. There is selective damage to the motor and sensory nerve… … The new mediacal dictionary
combined system disease — subacute combined degeneration of spinal cord; see under degeneration … Medical dictionary
combined sclerosis — subacute combined degeneration of spinal cord; see under degeneration … Medical dictionary
degeneration — 1. Deterioration; passing from a higher to a lower level or type. 2. A worsening of mental, physical, or moral qualities. 3. A retrogressive pathologic change in cells or tissues, in consequence of which their functions are often impaired or… … Medical dictionary
ataxic paraplegia — subacute combined degeneration of spinal cord; see under degeneration … Medical dictionary
posterolateral sclerosis — subacute combined degeneration of spinal cord; see under degeneration … Medical dictionary
Lichtheim syndrome — subacute combined degeneration of spinal cord; see under degeneration … Medical dictionary
Putnam-Dana syndrome — subacute combined degeneration of spinal cord (see under degeneration) … Medical dictionary
