Hypericin

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ImageFile=Hypericin.svg
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IUPACName=4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone
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Section1= Chembox Identifiers
CASNo=548-04-9
PubChem=5281051
SMILES=CC1=CC(=C2C3=C1C4=C5C(=C(C=C4C)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O
Section2= Chembox Properties
Formula=C₃₀H₁₆O₈
MolarMass=504.44324
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Hypericin is a red-coloured anthraquinone-derivative, which is together with Hyperforin one of the principal active constituents of Hypericum (Saint John's wort). Hypericin is believed to act as an antibiotic and non-specific kinase inhibitor. Hypericin may inhibit the action of the enzyme dopamine β-hydroxylase, leading to increased dopamine levels, although thus possibly decreasing norepinephrine and epinephrine.

The large chromophore system in the molecule means that it can cause photosensitivity when ingested beyond threshold amounts. Because hypericin accumulates preferentially on cancerous tissues, it is also used as an indicator of cancerous cells. In addition, hypericin is under research as an agent in photodynamic therapy, whereby a biochemical is absorbed by an organism to be later activated with spectrum-specific light from specialized lamps or laser sources, for therapeutic purposes.

External links

* cite web
url = http://www.delano.com/ReferenceArticles/Hypericin-Active.html
title = Hypericin: the active ingredient in Saint John’s Wort
accessdate =
accessmonthday = September 18
accessyear = 2006
author =
last = Oubre
first = Alondra
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date =
year = 1991
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