- KASH domains
KASH domains are conserved C-terminal
protein regions less than ~30amino acid s. KASH is anacronym for Klarsicht, ANC-1, Syne Homology. KASH domains always follow a transmembrane domain. Most proteins containing KASH domains are thought to be involved in the positioning of the nucleus in the cell. It is thought that KASH domains interact with proteins containingSUN domain s in the space between the outer and inner nuclear membranes to bridge thenuclear envelope and transfer force from the nucleoskeleton to the cytoplasmiccytoskeleton . KASH proteins are thought to largely localize to the outer nuclear membrane, although there are reports of inner nuclear membrane localization of some KASH protein isoforms [ [http://www.ncbi.nlm.nih.gov/pubmed/16237665?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum KASH 'n Karry: the KASH domain family of cargo-spe... [Bioessays. 2005 - PubMed Result ] ] .Examples of KASH proteins
"
Caenorhabditis elegans "
*UNC-83
*ANC-1
*ZYG-12Mammals
*Nesprins-1, 2, and 3 (also called Synes, Mynes, Nuance, Enaptin)"
Drosophila melanogaster "
*KlarsichtReferences
External links
* - KASH domain in
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