KASH domains

KASH domains

KASH domains are conserved C-terminal protein regions less than ~30 amino acids. KASH is an acronym for Klarsicht, ANC-1, Syne Homology. KASH domains always follow a transmembrane domain. Most proteins containing KASH domains are thought to be involved in the positioning of the nucleus in the cell. It is thought that KASH domains interact with proteins containing SUN domains in the space between the outer and inner nuclear membranes to bridge the nuclear envelope and transfer force from the nucleoskeleton to the cytoplasmic cytoskeleton. KASH proteins are thought to largely localize to the outer nuclear membrane, although there are reports of inner nuclear membrane localization of some KASH protein isoforms [ [http://www.ncbi.nlm.nih.gov/pubmed/16237665?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum KASH 'n Karry: the KASH domain family of cargo-spe... [Bioessays. 2005 - PubMed Result ] ] .

Examples of KASH proteins

"Caenorhabditis elegans"
*UNC-83
*ANC-1
*ZYG-12

Mammals
*Nesprins-1, 2, and 3 (also called Synes, Mynes, Nuance, Enaptin)

"Drosophila melanogaster"
*Klarsicht

References

External links

* - KASH domain in PROSITE


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • SUN domain — SUN (Sad1p, UNC 84) domains are conserved C terminal protein regions a few hundred amino acids long. SUN domains are usually found following a transmembrane domain and a less conserved region of amino acids. Most proteins containing SUN domains… …   Wikipedia

  • Kashgar — Infobox Settlement official name = Kashgar other name = native name = قەشقەر unicode|K̡ǝxk̡ǝr 喀什 nickname = settlement type = motto = imagesize = image caption = Kashgar is an oasis city in the Xinjiang Uygur Autonomous Region of the People s… …   Wikipedia

  • agriculture, origins of — Introduction  the active production of useful plants or animals in ecosystems that have been created by people. Agriculture has often been conceptualized narrowly, in terms of specific combinations of activities and organisms wet rice production… …   Universalium

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”