- Boromycin
drugbox
IUPAC_name =
CAS_number = 34524-20-4
ATC_prefix =
ATC_suffix =
PubChem = 6436027
DrugBank =
C=45|H=74|B=1|N=1|O=15
molecular_weight = 879.878 g/mol
bioavailability =
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routes_of_administration =Boromycin is a bacteriocidal
polyether -macrolide antibiotic . It was initially isolated from theStreptomyces strainStreptomyces antibioticus , and is notable for being the first natural product found to contain the element boron. It is effective against mostGram-positive bacteria, but is ineffective againstGram-negative bacteria. Boromycin kills bacteria by negatively affecting the cytoplasmic membrane, resulting in the loss of potassium ions from the cell.Anti-HIV activity
Recent studies have suggested that boromycin has potent anti-HIV activity. It was found to strongly inhibit the replication of the clinically isolated HIV-1 strain as well as the cultured strain
in vitro . Themechanism of action for the anti-HIV activity of boromycin is suggested to involve interfering with the later stage of HIV infection, and possibly the maturation step for the replication of HIV.References
*cite journal
author=Kohno J, Kawahata T, Otake T, Morimoto M, Mori H, Ueba N, Nishio M, Kinumaki A, Komatsubara S, Kawashima K.
title=Boromycin, an anti-HIV antibiotic
journal= Biosci Biotechnol Biochem
year= 1996
pages=1036–7
volume=60
issue = 6
doi =
*cite journal
title=On the Biosynthesis of Boromycin
journal= Journal of Organic Chemistry
year= 1981
pages=2661–2665
volume=46
url = http://pubs.acs.org/cgi-bin/abstract.cgi/joceah/1981/46/i13/f-pdf/f_jo00326a010.pdf?sessid=6006l3
doi=10.1021/jo00326a010
author=Chen, Tom S. S.
unused_data=Tom S. S. Chen, Ching-jer Chang, and Heinz G. Floss
*cite journal
author=R. Hütter, W. Keller-Schien, F. Knüsel, V. Prelog , G. C. Rodgers jr., P. Suter, G. Vogel, W. Voser, H. Zähner
title=Stoffwechselprodukte von Mikroorganismen. 57. Mitteilung. Boromycin
journal=Helv. Chim. Acta.
year= 1967
pages=1533–1539
volume=50
doi = 10.1002/hlca.19670500612
*cite journal
author=J. D. Dunitz, D. M. Hawley, D. Miklo, D. N. J. White, Yu. Berlin, R. Marui, V. Prelog
title=Structure of boromycin
journal= Helv. Chim. Acta.
year= 1971
pages=1709–1713
volume=54
doi = 10.1002/hlca.19710540624
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