Bruce B. Downs Boulevard

Infobox road
state=FL
name_notes=
type=FL
route=581
length_mi=3.6
length_km=5.8
established=
direction_a=South
direction_b=North
starting_terminus=
junction=
ending_terminus=
previous_type=FL
previous_route=580
next_type=FL
next_route=582

Infobox road
marker_

state=FL
name_notes=
type=County
route=581
length_mi=11.9
length_km=19.2
established=
direction_a=South
direction_b=North
starting_terminus=
junction=
ending_terminus=

Bruce B. Downs Boulevard is a major north-south arterial road in Hillsborough County, Florida, also designated as State Road 581 or County Road 581 in various places. It runs from Fowler Avenue in Tampa, to SR 54 in Wesley Chapel in Pasco County.

Formerly a section of 30th Street, it was renamed in 1984 by Hillsborough's Board of County Commissioners in honor of Bruce B. Downs, a deputy county administrator for public works. The road is the major thoroughfare through New Tampa, a booming part of the city of Tampa annexed during the 1980s, and traffic densities are well above the capacity the route was designed for, leading to calls for the route to be widened to a minimum of six lanes.