- 253 BC
* The second
Syrian Warbetween the Seleucids and the Ptolemies ends. Antiochus II regains much of Anatoliafrom Ptolemy II, including the cities of Miletusand Ephesus, and also the Phoenician coast.
* The war is concluded with the marriage of Antiochus to Ptolemy II's daughter, Berenice Syra. Antiochus divorces his previous wife, Laodice, and transfers the succession to Berenice's children.
* In recapturing the city of Miletus, Antiochus II overthrows the tyrant of the city. In response, the citizens worship him as a god in thanksgiving leading to the addition of Theos to Antiochus II's name.
* Alexander, Antigonus II's nephew and regent, leads a revolt in
Corinthwith Ptolemy II's help and declares himself an independent monarch. As a result, Antigonus loses Corinth and Chalcis, the two bases from which he has dominated southern Greece. As the Aetolians occupy Thermopylae, Antigonus II is cut off from Athensand the Peloponnese.
Macedonia's involvement in the second Syrian Warceases when Antigonus becomes preoccupied with the rebellion of Corinth and Chalcis, as well as an increase in enemy activity along Macedon's northern frontier.
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