Ecothiopate iodide

drugbox
IUPAC_name = 2-diethoxyphosphorylsulfanylethyl-trimethyl-ammonium iodide

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CAS_number = 6736-03-4
ATC_prefix = S01
ATC_suffix = EB03
ATC_supplemental =
PubChem = 10547
DrugBank = APRD00942
C=9 | H=23 | I=1 | N=1 | O=3 | P=1 | S=1
molecular_weight = 383.228 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
pregnancy_category =
legal_status =
routes_of_administration = Topical (eye drops)

Ecothiopate iodide (INN, also known as echothiophate) is a parasympathomimetic and organophosphate. It is a cholinesterase inhibitor.cite journal |author=Gabelt BT, Hennes EA, Seeman JL, Tian B, Kaufman PL |title=H-7 effect on outflow facility after trabecular obstruction following long-term echothiophate treatment in monkeys |journal=Invest. Ophthalmol. Vis. Sci. |volume=45 |issue=8 |pages=2732–6 |year=2004 |month=August |pmid=15277498 |doi=10.1167/iovs.04-0083 |url=http://www.iovs.org/cgi/pmidlookup?view=long&pmid=15277498]

Uses

It is used as an ocular antihypertensive in the treatment of chronic glaucoma and, in some cases, accommodative esotropia. It is available under several trade names such as Phospholine Iodide (Wyeth-Ayerst).

Ecothiopate binds irreversibly to cholinesterase. Because of the very slow rate at which echothiophate is hydrolyzed by cholinesterase, its effects can last a week or more. Adverse effects include muscle spasm and other systemic effects.

hortage

Wyeth Pharmaceuticals stopped manufacturing ecothiopate iodide (phospholine iodide) in the US in 2003. After contacting the American Academy of Ophthalmology (AAO), Wyeth rescinded their decision and, according to AAO public relations representative Michelle Stephens, the AAO and Wyeth were in talks for about a year about manufacturing it. [ [http://www.escrs.org/eurotimes/March2003/echo.asp Eurotimes article: "Echothiophate iodide shortage leaves US specialists struggling to find alternative for acute cases"] ]

In the meantime, a worldwide shortage of the drug has occurred.

ources

*Brenner, G. M. (2000). "Pharmacology". Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6.
*Canadian Pharmacists Association (2000). "Compendium of Pharmaceuticals and Specialties" (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4.
*Rang, H. P. (2003). "Pharmacology". Edinburgh: Churchill Livingstone, p. 146. ISBN 0-443-07145-4.