Ryanodine

Ryanodine

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Section1 = Chembox Identifiers
CASNo = 15662-33-6
PubChem = 5114
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MeSHName = Ryanodine
Section2 = Chembox Properties
Formula = C25H35NO9
MolarMass = 493.547 g/mol
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Ryanodine is a poisonous alkaloid found in the South American plant "Ryania speciosa" (Flacourtiaceae). It was originally used as an insecticide.

The compound has extremely high affinity to the ryanodine receptor, a group of calcium channels found in skeletal and heart muscle cells. It binds with such high affinity to the receptor that it was used as a label for the first purification of that class of ion channels and gave its name to it.

At nanomolar concentrations, ryanodine locks the receptor in a half-open state, whereas it fully closes them at micromolar concentration. The effect of the nanomolar-level binding is that ryanodine causes release of calcium from calcium stores in the sarcoplasmic reticulum leading to massive muscular contractions.

References

* Bertil Hille, "Ionic Channels of Excitable Membranes", 2nd edition, Sinauer Associates, Sunderland, MA, 01375, ISBN 0-87893-323-9


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Look at other dictionaries:

  • Ryanodine — Général No CAS …   Wikipédia en Français

  • ryanodine — Drug that blocks the release of calcium from the sarcoplasmic reticulum of skeletal muscle. Ryanodine binding proteins have also been found in the CNS …   Dictionary of molecular biology

  • Ryanodine receptor 2 — (cardiac), also known as RYR2, is a human gene. PBB Summary section title = summary text = This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel,… …   Wikipedia

  • Ryanodine receptor — protein Name = ryanodine receptor 1 (skeletal) caption = width = HGNCid = 10483 Symbol = RYR1 AltSymbols = MHS, MHS1, CCO EntrezGene = 6261 OMIM = 180901 RefSeq = NM 000540 UniProt = P21817 PDB = ECnumber = Chromosome = 19 Arm = q Band = 13.1… …   Wikipedia

  • ryanodine receptor — [from its sensitivity to the plant alkaloid ryanodine] a tetrameric receptor containing a calcium ion channel, located in the sarcoplasmic reticulum of muscle cells and the endoplasmic reticulum of nerve cells; it exists in three isoforms, each… …   Medical dictionary

  • ryanodine — noun A poisonous alkaloid found in the South American plant Ryania speciosa, originally used as an insecticide …   Wiktionary

  • ryanodine — An alkaloid obtained from Ryania speciosa (family Flacourtiaceae); has a disruptive effect on calcium storage in cardiac and skeletal muscle, where it produces sustained contractions; used as an insecticide …   Medical dictionary

  • ryanodine — ry·an·o·dine …   English syllables

  • ryanodine — rīˈanəˌdēn, də̇n noun ( s) Etymology: irregular from New Latin Ryania (genus name of Ryania speciosa) + English ine : a crystalline insecticidal alkaloid C25H35NO9 that is toxic to mammals and is obtained from the root and stem of the ryania …   Useful english dictionary

  • Recepteur de la ryanodine — Récepteur de la ryanodine Les récepteurs de la ryanodine constituent une classe de canal calcique dans diverses formes de muscles. RyR1 s exprime dans les muscles du squelette RyR2 s exprime dans le myocarde. RyR3 s exprime dans le cerveau. Ces… …   Wikipédia en Français

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