Adenophostin

Chembox new
Name=Adenophostin A
ImageFile=Adenophostin.pngImageSize=200px
IUPACName= [(2"R",3"R",4"R",5"R")-2-(6-Amino-9-purinyl)-4- [(2"R",3"R",4"R",5"R",6"R")-3-hydroxy-6-(hydroxymethyl)-4,5-diphosphonooxy-2-tetrahydropyranyl] oxy] -5-(hydroxymethyl)-3-tetrahydrofuranyl] dihydrogen phosphate
OtherNames=
Section1= Chembox Identifiers
CASNo=
PubChem=123695
SMILES=C1=NC2=C(C(=N1)N)N=CN2 [C@H] 3 [C@@H] ( [C@@H] ( [C@H] (O3)CO)O [C@@H] 4 [C@@H] ( [C@H] ( [C@@H] ( [C@H] (O4)CO)OP(=O)(O)O)OP(=O)(O)O)O)OP(=O)(O)O
Section2= Chembox Properties
Formula=C₁₆H₂₆N₅O₁₈P₃
MolarMass=669.321623
Appearance=
Density=
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BoilingPt=
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Section3= Chembox Hazards
MainHazards=
FlashPt=
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Adenophostin is a potent inositol triphosphate (IP3) receptor agonist, but is much more potent than IP3.

IPR3 is a ligand-gated intracellular Ca²⁺ release channel that plays a central role in modulating cytoplasmic free Ca²⁺ concentration (Ca²⁺i). Adenophostin A is structurally different from IP3 but could elicit distinct calcium signals in cells.

References