Recognition sequence

Recognition sequence

The recognition sequence, also referred to as recognition site, of any DNA-binding protein motif that exhibits binding specificity, refers to the DNA sequence (or subset thereof), to which the domain is specific.

The transcription factor Sp1 for example, binds the sequences 5'-(G/T)GGGCGG(G/A)(G/A)(C/T)-3', where (G/T) indicates that the domain will bind a guanine or thymine at this position.

The Restriction endonuclease PstI recognizes, binds, and cleaves the sequence 5'-CTGCAG-3'.

See also

*DNA-binding domain

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