Tositumomab

Tositumomab

drugbox
type = mab


source = Mouse
target = CD20
CAS_number = 192391-48-3
ATC_prefix = V10
ATC_suffix = XA53
ATC_supplemental =
PubChem =
DrugBank = BTD00085
C=6416 | H=9874 | N=1688 | O=1987 | S=44
molecular_weight = 143859.7 g/mol
bioavailability =
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elimination_half-life =
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Tositumomab is a monoclonal antibody derived from immortalized mouse cells. It is a IgG2a anti-CD20 antibody and is covalently bound to 131I. 131I emits both beta and gamma radiation and decays with a half-life of 8 days.

Clinical trials have established the efficacy of tositumomab in patients with relapsed or chemotherapy/rituxan refractory follicular lymphoma.

The drug was developed by Dr. Mark Kaminski and Dr. Richard Wahl. It is manufactured by Corixa. It sells in the U.S. under the trade name Bexxar.

There is some evidence that it may cause a smaller decrease in platelet counts than ibritumomab tiuxetan does.cite journal |author=Jacene HA, Filice R, Kasecamp W, Wahl RL |title=Comparison of 90Y-ibritumomab tiuxetan and 131I-tositumomab in clinical practice |journal=J. Nucl. Med. |volume=48 |issue=11 |pages=1767–76 |year=2007 |pmid=17942813 |doi=10.2967/jnumed.107.043489 |url=http://jnm.snmjournals.org/cgi/pmidlookup?view=long&pmid=17942813]

References


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