Swainsonine

Swainsonine

Chembox new
ImageFile = Swainsonine structure.png ImageSize = 200px
IUPACName = ("1S,2R,8R,8aR")-1,2,3,5,6,7,8,8a-Octahydroindolizine-1,2,8-triol
OtherNames = Tridolgosir
Section1 = Chembox Identifiers
CASNo = 72741-87-8
PubChem = 51683
SMILES = C1C [C@H] ( [C@@H] 2 [C@@H] ( [C@@H] (CN2C1)O)O)O
Section2 = Chembox Properties
C=8 | H=15 | N=1 | O=3
MolarMass = 173.2
Appearance =
Density =
MeltingPt = 143-144 °C
BoilingPt =
Solubility = 10 mg/1 mL
Section3 = Chembox Hazards
MainHazards =
FlashPt =
Autoignition =

Swainsonine is a potent inhibitor of Golgi alpha-mannosidase II, immunomodulator and potential anticancer agent. Disruption of Golgi alpha-mannosidase II with swainsonine induces hybrid-type glycans. These glycans have a Man5GlcNAc2 core with processing on the 3-arm that resembles so-called complex-type glycans.

The pharmacological properties of this product have not been fully investigated.

Handling Instructions

* Soluble in water (10 mg/1 ml) and ethanol
* Use caution when handling.
* This product must not be used in humans
* Store between 0-4 ˚C for up to 1 year
* Store or 20 ˚C for up to 3 months
* Disposal: A

References

* [http://www.logannaturalproducts.com/swainsonine.php Swainsonine] at Logan Natural Products


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