ADAM protein

ADAM protein (A Disintegrin And Metalloproteinase protein) is a family of peptidase proteins [cite journal |author=Wolfsberg TG, Straight PD, Gerena RL, "et al" |title=ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain |journal=Dev. Biol. |volume=169 |issue=1 |pages=378–383 |year=1995 |pmid=7750654 |doi=10.1006/dbio.1995.1152] . ADAMs are also known as the Adamalysin family. ADAMs are classified as Sheddases because they cut off or shed extracellular portions of transmembrane proteins. For example, ADAM 10 can cut off part of the HER2 receptor, activating it [cite journal | last = Liu | first = P.C. | coauthors = et. al | url = http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16627989 | title = Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells. | journal = Cancer Biology and Therapy | volume = 6 | pages = 657–664 | year = 2006] . Therapeutic ADAM inhibitors can potentiate anti-cancer therapyFact|date=March 2007.

It is categorized under EC number|3.4.24.46.

Types include:
* ADAMTS2
* ADAMTS13
* ADAMTS5
* ADAM17

References

External links

*
* http://www.healthvalue.net/sheddase.html