- HLA-B27
Disease associations
pondylarthropathies
The relationship between HLA-B27 and many diseases has not yet been fully elucidated. Though it is associated with a wide range of
pathology , it does not appear to be the sole mediator in development ofdisease .Fact|date=August 2008 For example, while 90% of people withankylosing spondylitis (AS) are HLA-B27 positive, only a fraction of people with HLA-B27 ever develop AS. This raises two important questions: why don't all HLA-B27 positive people develop AS, and why do some people who are HLA-B27 negative develop it?Fact|date=August 2008 The literature is inconclusive, though several theories have been suggested. Research however has been discontinued in many countries due to lack of funding.Fact|date=August 2008Juvenile Spondylarthropathies
In Croatian children, two B27 alleles were found associated with disease, B*2702, B*2705.cite journal |author=Harjacek M, Margetić T, Kerhin-Brkljacić V, Martinez N, Grubić Z |title=HLA-B*27/HLA-B*07 in combination with D6S273-134 allele is associated with increased susceptibility to juvenile spondyloarthropathies |journal=Clin. Exp. Rheumatol. |volume=26 |issue=3 |pages=498–504 |year=2008 |pmid=18578977 |doi= |url=] The study showed also B*0702 in coorperation with B*27, the HLA-B*07/B*27 combination with D6S273-134 genomic marker allele and was found not to be the result of linkage disequilibrium. B*2795 was found to be dominant allele associated.
Associated pathology
In addition to its connection with AS, HLA-B27 is implicated in
Reiter's syndrome , certain eye disorders such as acute anterioruveitis andiritis ,psoriatic arthritis andulcerative colitis . Reiter's syndrome then again, is statistically associated with AS.ee also
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Human leukocyte antigen External links
* by A. Luisa Di Lorenzo, MBBCh
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*References
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