Propantheline bromide

Propantheline bromide

drugbox



IUPAC_name = N,N-Diisopropyl-N-methyl-N- [2-(xanthen-9-ylcarbonyloxy)ethyl] ammonium bromide
CAS_number=298-50-0
CAS_supplemental=CAS|50-34-0
ATC_prefix=A03
ATC_suffix=AB05
PubChem = 9279
DrugBank=APRD00177
C=23|H=30|N=1|O=3
molecular_weight=368.489 g/mol
bioavailability=
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metabolism=
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Propantheline bromide (INN) is an antimuscarinic agent used for the treatment of excessive sweating (hyperhidrosis), cramps or spasms of the stomach, intestines (gut) or bladder, and involuntary urination (enuresis). It can also be used to control the symptoms of irritable bowel syndrome and similar conditions.

Indications

By relaxing the gut muscle, propantheline can relieve pain in conditions caused by spasm of the muscle in the gut. Relaxing the smooth muscle in the bladder prevents the involuntary spasms that can allow leakage of urine from the bladder in the condition known as enuresis (involuntary urination in adults). Propantheline can also be used to treat excessive sweating because acetylcholine block also reduces secretions such as sweat and tears.

Adverse effects

Side effects include tachycardia, constipation, hypersensitivity to light, dry mouth, and urinary retention.

Mechanism of action

Propantheline is one of a group of antispasmodic medications which work by blocking the action of the chemical messenger acetylcholine, which is produced by nerve cells, to muscarinic receptors present in various smooth muscular tissues, in places such as the gut, bladder and eye. Normally, the binding of acetylcholine induces involuntary smooth muscular contractions.


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Look at other dictionaries:

  • propantheline bromide — The isopropyl analogue of methantheline bromide; an anticholinergic agent. * * * pro·pan·the·line bromide prō pan thə .lēn n an anticholinergic drug C23H30BrNO3 used esp. in the treatment of peptic ulcer called also propantheline see …   Medical dictionary

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  • propantheline bromide — /proh pan theuh leen , lin/, n. Pharm. a substance, C23H30BrNO3, used in the treatment of peptic ulcers. [1950 55; by rearrangement of parts of its chemical name] * * * …   Universalium

  • propantheline bromide — /proh pan theuh leen , lin/, n. Pharm. a substance, C23H30BrNO3, used in the treatment of peptic ulcers. [1950 55; by rearrangement of parts of its chemical name] …   Useful english dictionary

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  • Pro-Banthine — Pro Ban·thine ( )prō ban .thēn n a preparation of propantheline bromide formerly a U.S. registered trademark * * * Pro Ban·thine (pro ban thīnґ) trademark for preparations of propantheline bromide …   Medical dictionary

  • Hyperhidrosis — Primary hyperhidrosis is the condition characterized by abnormally increased perspiration, in excess of that required for regulation of body temperature. igns and symptomsHyperhidrosis can either be generalized or localized to specific parts of… …   Wikipedia

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