Sneddon syndrome

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DiseasesDB = 12257
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OMIM = 182410
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MeshID = D018860

Sneddon syndrome is a form of arteriopathy characterized by several symptoms, including:

* cerebrovascular disease
* Lividoid reticularis (livedoid vasculitis)
* hypertension

It is named for Ian Bruce Sneddon. [WhoNamedIt|synd|1732] cite journal |author=Sneddon IB |title=Cerebrovascular lesions and livedo reticularis. |journal=Br. J. Dermatol. |volume=77 |issue= |pages=180–5 |year=1965 |month=April |pmid=14278790 |doi= |url=]

In 1965 Dr. Sneddon reported 6 patients that had a distinct skin rash and cerebral vascular accidents (strokes). This association has since been reported many times, but the precise etiology still remains elusive. The skin rash, termed livedo reticularis, is not specific to this disease and can be seen in numerous conditions (systemic vasculitis, Hepatitis C among others), but most of the time it isn't associated with anything. It refers to a charateristic net-like, pink to red to blue discoloration of the skin. When this rash occurs with cerebrovascular disease it is considered Sneddon syndrome. This syndrome affects adult women. Usally the rash appears first followed by a stroke. Both systemic lupus erythematosus and antiphospholipid antibodies are associated with Sneddon syndrome. The condition may be inhereited in an autosomal dominant fashion.

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