Fructose 1,6-bisphosphate

Chembox new
ImageFile=Beta-D-fructose-1,6-bisphosphate wpmp.pngImageSize=150px
IUPACName=
OtherNames=
Section1= Chembox Identifiers
CASNo=488-69-7
PubChem=172313
SMILES=C(C1C(C(C(O1)(COP(=O)(O)O)O)O)O)OP(=O)(O)O
MeSHName=fructose-1,6-diphosphate
Section2= Chembox Properties
Formula=C₆H₁₄O₁₂P₂
MolarMass=340.116
Appearance=
Density=
MeltingPt=
BoilingPt=
Solubility=
Section3= Chembox Hazards
MainHazards=
FlashPt=
Autoignition=

Fructose 1,6-phosphate is fructose sugar phosphorylated on carbons 1 and 6 (ie. is a fructosephosphate). The β-D-form of this compound is very common in cells. The vast majority of glucose and fructose entering a cell will become converted to fructose 1,6-phosphate at some point.

Fructose 1,6-phosphate in glycolysis

Fructose 1,6-phosphate lies within the glycolysis metabolic pathway and is produced by phosphorylation of fructose 6-phosphate. It is in turn broken down into two compounds; glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. It is an allosteric activator of pyruvate kinase.

Complex biochemical reaction
reaction_A_major_substrate_1=β-D-fructose 6-phosphate
reaction_A_major_substrate_1_

reaction_A_major_substrate_1_stoichiometric_constant=
reaction_A_major_substrate_2=
reaction_A_major_substrate_2_

reaction_A_major_substrate_2_stoichiometric_constant=
reaction_A_foward_enzyme=6-phosphofructo 1-kinase
reaction_A_reverse_enzyme=Hexose diphosphatase
reaction_A_reaction_direction_(foward/reversible/reverse)=reversible
reaction_A_minor_reverse_product(s)=P_i
reaction_A_minor_reverse_substrate(s)=H₂O
reaction_A_minor_foward_substrate(s)=ATP
reaction_A_minor_foward_product(s)=ADP
reaction_A_major_product_1=β-D-fructose 1,6-phosphate
reaction_A_major_product_1_

reaction_A_major_product_1_stoichiometric_constant=
reaction_A_major_product_2=
reaction_A_major_product_2_

reaction_A_major_product_2_stoichiometric_constant=
reaction_B_foward_enzyme=Fructose bisphosphate aldolase
reaction_B_reverse_enzyme=Fructose bisphosphate aldolase
reaction_B_reaction_direction_(foward/reversible/reverse)=reversible
reaction_B_minor_foward_substrate(s)=
reaction_B_minor_foward_product(s)=
reaction_B_minor_reverse_product(s)=
reaction_B_minor_reverse_substrate(s)=
reaction_B_major_product_1=D-glyceraldehyde 3-phosphate
reaction_B_major_product_1_

reaction_B_major_product_1_stoichiometric_constant=
reaction_B_major_product_2=dihydroxyacetone phosphate
reaction_B_major_product_2_

reaction_B_major_product_2_stoichiometric_constant=

"The numbering of the carbon atoms indicates the fate of the carbons according to their position in fructose 6-phosphate."

Fructose 1,6-phosphate isomerism

Fructose 1,6-phosphate has only one biologically active isomer, the β-D-form. There are many other isomers, analogous to those of fructose.

ee also

* Fructose 2,6-bisphosphate