- Emde degradation
The Emde degradation (also called Emde-reaction or Emde-reduction) is a method for the reduction of a
quaternary ammonium cation to a tertiaryamine withsodium amalgam [ H. Emde. "Ber deutsch chem Ges" 42 (1909) p2590] [ W Pötsch. "Lexikon bedeutender Chemiker" (VEB Bibliographisches Institut Leipzig, 1989) (ISBN 3817110553 ] [ M B Smith, J March. "March's Advanced Organic Chemistry" (Wiley, 2001) (ISBN 0-471-58589-0)]This
organic reaction was first described in 1909 by the German chemist Hermann Emde and was for a long time of great importance in structure elucidation of manyalkaloid s, for example that ofephedrine .Alternative
reducing agent s exist for this reaction; for instance,lithium aluminium hydride .ee also
* Related reactions are the
Hofmann elimination and theVon Braun reaction References
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