Yotari

The yotari mouse is an autosomal recessive mutant.Yoneshima H, Nagata E, Matsumoto M, Yamada M, Nakajima K, Miyata T, Ogawa M, Mikoshiba K. (1997) A novel neurological mutant mouse, yotari, which exhibits reeler-like phenotype but expresses CR-50 antigen/reelin. Neurosci Res. 29(3):217-23. PMID 9436647] It has a mutated "disabled homolog 1" (Dab1) gene. Sheldon M, Rice DS, D'Arcangelo G, Yoneshima H, Nakajima K, Mikoshiba K, Howell BW, Cooper JA, Goldowitz D, Curran T. (1997) Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice. Nature. 389(6652):730-3. PMID 9338784 ] This mutant mouse is recognized by unstable gait ("Yota-ru" in Japanese means "unstable gait") and tremor and by early deaths around the time of weaning. The cytoarchitectures of cerebellar and cerebral cortices and hippocampal formation of the yotari mouse are abnormal. These malformations resemble those of reeler mouse.

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