Autosomal dominant hypophosphatemic rickets

Autosomal dominant hypophosphatemic rickets

Autosomal dominant hypophosphatemic rickets (ADHR) is a rare hereditary disease in which excessive loss of phosphate in the urine leads to poorly formed bones (rickets), bone pain, and tooth abscesses. ADHR is caused by a mutation in the fibroblast growth factor 23 (FGF23). ADHR affects men and women equally; symptoms may become apparent at any point from childhood through early adulthood. Blood tests reveal low levels of phosphate (hypophosphatemia) and inappropriately normal levels of vitamin D. Treatment consists of increasing phosphate intake and high doses of vitamin D. Occasionally, hypophosphatemia may improve over time as urine losses of phosphate partially correct.

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  • autosomal dominant hypophosphatemic rickets — (ADHR), autosomal dominant vitamin D–resistant rickets a form of familial hypophosphatemic rickets with autosomal dominant inheritance and caused by mutation in the FGF23 gene (locus: 12p13.3), which encodes a member of the fibroblast growth… …   Medical dictionary

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  • Rickets — A disease of infants and children that disturbs normal bone formation (ossification). Rickets is a failure to mineralize bone. This softens bone (producing osteomalacia) and permits marked bending and distortion of bones. Up through the first… …   Medical dictionary

  • hypophosphatemic bone disease — an autosomal dominant disorder clinically resembling a mild form of X linked hypophosphatemia and similarly due to a defect in renal tubular function, but usually showing osteomalacia without radiographic evidence of rickets and responding to… …   Medical dictionary

  • ADHR — autosomal dominant hypophosphatemic rickets …   Medical dictionary

  • Fibroblast growth factor 23 — or FGF23 is gene which is a member of the fibroblast growth factor (FGF) family and encodes a protein which is responsible for phosphate metabolism.FGF family members possess broad mitogenic and cell survival activities and are involved in a… …   Wikipedia

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