Base analog

Base analog

A base analog is a chemical that can substitute for a normal nucleobase in nucleic acids.

A common example would be 5-bromouracil (5BU), the abnormal base found in the mutagenic nucleotide analog BrdU. When a nucleotide containing 5-bromouracil is incorporated into the DNA, it is most likely to pair with adenine; however, it can spontaneously shift into another isomer which pairs with a different nucleobase, guanine. If this happens during DNA replication, a guanine will be inserted opposite the base analog, and in the next DNA replication, that guanine will pair with a cytosine. This results in a change in one base pair of DNA, specifically a transition mutation.

ee also

* Antimetabolite

References

*Griffiths AJ, Wessler SR, Lewontin RC, Gelbart WM, Suzuki DT, Miller JH. "Introduction to Genetic Analysis", 8th ed. New York:W.H.Freeman and Co, 2005.


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Base pair — In molecular biology and genetics, the linking between two nitrogenous bases on opposite complementary DNA or certain types of RNA strands that are connected via hydrogen bonds is called a base pair (often abbreviated bp). In the canonical Watson …   Wikipedia

  • Analog sound vs. digital sound — Analog sound versus digital sound compares the two ways in which sound is recorded and stored. Actual sound waves consist of continuous variations in air pressure. Representations of these signals can be recorded in either digital or analog… …   Wikipedia

  • Analog signal — An analog or analogue signal is any continuous signal for which the time varying feature (variable) of the signal is a representation of some other time varying quantity, i.e analogous to another time varying signal. It differs from a digital… …   Wikipedia

  • Base station — The term base station can be used in the context of land surveying, wireless computer networking, and wireless communications.Land surveyingIn the context of external land surveying, a base station is a GPS receiver at an accurately known fixed… …   Wikipedia

  • Base (Chemie) — Basen (griechisch βάση, basé – die Ausgangs , Grundlage, das Fundament ) sind im engeren Sinne alle Verbindungen, die in wässriger Lösung in der Lage sind, Hydroxid Ionen (OH−) zu bilden, also den pH Wert einer Lösung zu erhöhen. Hydroxid Ionen… …   Deutsch Wikipedia

  • Comparison of analog and digital recording — This article compares the two ways in which sound is recorded and stored. Actual sound waves consist of continuous variations in air pressure. Representations of these signals can be recorded using either digital or analog techniques. An analog… …   Wikipedia

  • Digital-to-analog converter — For digital television converter boxes, see digital television adapter. 8 channel digital to analog converter Cirrus Logic CS4382 as used in a soundcard. In electronics, a digital to analog converter (DAC or D to A) is a device that converts a… …   Wikipedia

  • Single Base Extension — Unter Single Base Extension (SBE) wird eine biochemische Reaktion verstanden, die der Genotypisierung von SNPs (Single Nucleotide Polymorphisms) dient. Der SBE geht im Regelfall eine PCR (Polymerase Kettenreaktion) voraus. Inhaltsverzeichnis 1… …   Deutsch Wikipedia

  • Les montages de base de l'amplificateur opérationnel — Montages de base de l amplificateur opérationnel La représentation électrique d un amplificateur opérationnel varie suivant les pays Les applications de l amplificateur opérationnel sont divisées en deux grandes catégories suivant la nature de la …   Wikipédia en Français

  • Montages De Base De L'amplificateur Opérationnel — La représentation électrique d un amplificateur opérationnel varie suivant les pays Les applications de l amplificateur opérationnel sont divisées en deux grandes catégories suivant la nature de la réaction : Si elle s opère sur l entrée… …   Wikipédia en Français

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”