Deb or DEB may mean:
- deb (file format), a software package format used by the Debian project
- A débutante
- Deborah, a name
- Eugene Debs, a politician
- Nabakrishna Deb, a nobleman
- Dynamic energy budget
- Drug eluting balloon, a medical tool for angioplasty
- Debrecen International Airport, IATA airport code
- Deb Shops, an American retail clothing chain
- The second album by Souad Massi
- DEB, the abbreviation for Epidermolysis bullosa dystrophica
- D.E.B (Dome Environment Builder)
- The Digital Economy Bill, a bill passing before the UK Parliament.
- DEB, the abbreviation for the German Ice Hockey Federation, Deutscher Eishockey Bund
- Deb (뎁), a Korean musician.
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