Transducin

Transducin (also called G_t) is a heterotrimeric G protein that is naturally expressed in vertebrate retina rods and cones (a different Transducin gene is expressed in each cell type). Heterotrimeric Transducin (alpha-beta-gamma subunits) is activated by a conformational change in rhodopsin due to the absorption of a photon by rhodopsin's active group retinal; Activation causes the GDP bound to the alpha subunit to be exchanged with GTP from solution and results in activated alpha dissociating from beta-gamma. Active Transducin-alpha then causes cyclic GMP Phosphodiesterase to increase its activity, thereby lowering the concentration of cGMP, an intracellular second-messenger molecule. Decrease in cGMP concentration leads to the closure of cGMP-regulated Na⁺ and Ca²⁺ ion channels and a hyperpolarized membrane potential. This chain of signaling events is also called "the vertebrate phototransduction cascade".

The termination of Transducin activity occurs when (active) GTP bound Transducin is hydrolyzed to Transducin-GDP, a process which is accelerated by a complex containing an RGS ("Regulator of G-protein signaling")-protein and the gamma-subunit of the effector, cyclic GMP Phosphodiesterase.

Genes

*,gene|GNAT2,gene|GNAT3

External links

*