Pehr Victor Edman

Infobox Scientist
name = Pehr Victor Edman
caption = Taken in 1968, Photographer unknown
birth_date = birth date|1916|4|14|mf=y
birth_place = Stockholm, Sweden
death_date = death date and age|1977|3|19|1916|4|14|mf=y
death_place = Munich, Germany
residence = Sweden, Australia, United States, Germany
nationality = Swedish (1916-62)
Australian (1962-77)
field = Biochemistry
work_institution = Rockefeller Institute of Medical Research, Princeton University, University of Lund, St. Vincent's School of Medical Research, Max-Planck-Institut of Biochemistry
doctoral_advisor = Eric Jorpes
alma_mater = Karolinska Institutet
known_for = Edman degradation, sequenator

Pehr Victor Edman (April 14, 1916 — March 19, 1977) was a Swedish biochemist. He developed a method for sequencing proteins, the Edman degradation.

Early life

Edman was born in Stockholm, Sweden. In 1935 he started studying medicine at Karolinska Institutet, where he became interested in basic research. After graduation he stayed at Karolinska Institutet, where he was working towards his doctoral degree with Professor Eric Jorpes. His research was interrupted by the outbreak of World War II, where he was drafted to serve in the Swedish army. After the war, he was promoted to work on the purification and characterization of Angiotensin from bovine blood.

Developing the Edman Degradation

At the time Edman started working on Angiotensin, it was just being recognized that proteins are distinct entities with a defined molecular mass, electric charge and structure. This inspired Edman to develop a method, that could be used to determine the sequence of amino acids in the protein. In 1947 he was awarded a travel stipend to go to Rockefeller Institute of Medical Research at Princeton University. When he returned to Sweden in 1950 to be an Assistant Professor at the University of Lund. In 1950 he published his first paper using the method later known as Edman degradation, to determine the sequence of a protein. To his death he continued to work to improve the method to be able to determine longer stretches with smaller amounts of sample.

Late career

In 1957 he moved to Australia to be the director of St. Vincent's School of Medical Research. In 1967 he successfully developed an automated protein sequencer, called the sequenator, with his assistant Geoffrey Begg.

In 1972 he moved to the Max-Planck-Institut of Biochemistry, Martinsried near Munich. He worked with his second wife, Agnes Henschen, and she used Edman's method to sequence fibrinogen.

In 1977 Edman died of a brain tumor after a short coma.

External links

* [http://www.adb.online.anu.edu.au/biogs/A140089b.htm Australian Dictionary of Biography]
* [http://www.science.org.au/academy/memoirs/edman.htm Australian Academy of Science Biographical memoirs]
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=341414&dopt=Abstract Appreciation by B. Blombäck]