Endolysin

Endolysin

Endolysin is a generic term describing an enzyme that lyses a bacterial membrane.

At the end of the bacteriophage replication cycle, bacteriophages have to release their newly formed progeny. The major barrier to overcome is the peptidoglycan. To degrade this layer, bacteriophages contain endolysins.

Depending on the bond these enzymes cleave, we can distinguish muramidases (lysozyme), transglycosylases, amidases or endopeptidases.


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  • Endolysin — En|do|ly|sin 〈n. 11; meist Pl.; Med.〉 im Zelleninnern auftretendes (Bakterio )Lysin, das Bakterien zersetzt [<Endo... + Lysin] …   Universal-Lexikon

  • endolysin — en·dol·y·sin (en dolґĭ sin) [endo + lysin] a bactericidal substance existing in cells, acting directly on bacteria, e.g., leukin …   Medical dictionary

  • Endolysin — En|do|ly|sin 〈n.; Gen.: s, Pl.: e; meist Pl.〉 im Zelleninnern auftretendes (Bakterio )Lysin, das Bakterien zersetzt [Etym.: <Endo… + Lysin] …   Lexikalische Deutsches Wörterbuch

  • Endolysin — Endo|lysi̱n [zu ↑endo... u. gr. λυειν = lösen, auflösen] s ; s, e (meist Mehrz.): in den Zellen vorkommende bakterienabtötende Substanzen …   Das Wörterbuch medizinischer Fachausdrücke

  • Endolysin — En|do|ly|sin das; s, e (meist Plur.) <zu ↑endo... u. ↑Lysin> weißen Blutkörperchen entstammender, Bakterien abtötender Stoff …   Das große Fremdwörterbuch

  • Bacteriophage — This article is about a biological infectious particle; for other uses, see phage (disambiguation). A bacteriophage (from bacteria and Greek φάγειν phagein to eat ) is any one of a number of viruses that infect bacteria. The term is commonly used …   Wikipedia

  • Lambda phage — Taxobox color = violet name = Enterobacteria phage λ image width = 200px image caption = virus group = I ordo = Caudovirales familia = Siphoviridae subfamily = genus = λ like viruses species = λ Phage Enterobacteria phage λ (lambda phage) is a… …   Wikipedia

  • Phage therapy — is the therapeutic use of bacteriophages to treat pathogenic bacterial infections. Although extensively used and developed mainly in former Soviet Union countries for about 90 years, this method of therapy is still being tested elsewhere for… …   Wikipedia

  • Lysozym — C (Gallus gallus) Struktur von Lysozym nach PDB  …   Deutsch Wikipedia

  • Phagentherapie — Ein Phage injiziert sein Genom in eine Bakterienzelle …   Deutsch Wikipedia

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