Polysome

Polysome

Polyribosomes (or polysomes) are a cluster of ribosomes, bound to a mRNA molecule, first discovered and characterized by Jonathan Warner, Paul Knopf, and Alex Rich in 1963.cite journal |author=Warner JR, Knopf PM, Rich A |title=A multiple ribosomal structure in protein synthesis |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=49 |issue= |pages=122–9 |year=1963 |url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=13998950 |pmid=13998950 |doi=10.1073/pnas.49.1.122 [http://www.garfield.library.upenn.edu/classics1977/A1977DV63600002.pdf Summary] ] Polyribosomes read one strand of mRNA simultaneously, helping to synthesize the same protein at different spots on the mRNA, mRNA being the "messenger" in the process of protein synthesis. They may appear as clusters, linear arrays, or rosettes in routine: this is aided by the fact that mRNA is able to be twisted into a circular formation, creating a cycle of rapid ribosome recycling, and utilization of ribosomes. 5' 7-methylguanosine cap and 3' polyA tail aids in this process.cite book |author=Harvey Lodish et al. |title=Molecular cell biology |publisher=Scientific American Books |location=New York |year=1999 |isbn=0-7167-3136-3 |chapter=4.5. Stepwise Formation of Proteins on Ribosomes |chapterurl=http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mcb.section.901#914]

Polyribosomes can be found in three forms: free, cytoskeletal bound and membrane bound.

External links

* [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mboc4.figgrp.1090 Theoretical and experimental structure of polysome]

References


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  • polysome — [ pɔlizom ] n. m. • 1965; mot angl. 1962, abrév. de polyribosome ♦ Biochim. ⇒ polyribosome. ● polysome nom masculin Ensemble des ribosomes fixés en même temps à un même A.R.N. messager. ● polysome (synonymes) nom masculin Ensemble des ribosomes… …   Encyclopédie Universelle

  • polysome — polysome. См. эргосома. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • polysome — [päl′i sōm΄] n. [ POLY + SOME3] a collection of ribosomes, probably connected by a single thread of RNA, in which protein synthesis occurs …   English World dictionary

  • Polysome — Un polysome ou polyribosome est un ensemble de ribosomes reliés entre eux par un ARN messager. Cet ensemble a l aspect d un collier de perles en forme de spirale. Ils sont le lieu de la synthèse des protéines qu ils soient sous forme libre dans… …   Wikipédia en Français

  • polysome — poliribosoma statusas T sritis augalininkystė apibrėžtis Ribosomų kompleksas, sujungtas vienos informacinės RNR molekulės. atitikmenys: angl. polyribosome; polysome rus. полирибосома; полисома ryšiai: sinonimas – polisoma …   Žemės ūkio augalų selekcijos ir sėklininkystės terminų žodynas

  • polysome — noun Date: 1962 polyribosome …   New Collegiate Dictionary

  • polysome — n. [Gr. polys, many; soma, body] A multiribosomal structure consisting of ribosomes bound by messenger RNA; very active in protein synthesis …   Dictionary of invertebrate zoology

  • polysome — See polyribosome …   Dictionary of molecular biology

  • polysome — /pol ee sohm /, n. Biol. a complex of ribosomes strung along a single strand of messenger RNA that translates the genetic information coded in the messenger RNA during protein synthesis. Also called polyribosome. [1960 65; POLY + (RIBO)SOME] * *… …   Universalium

  • polysome — noun a polyribosome …   Wiktionary

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