Bronidox

Bronidox (Registered Tradmark of Cognis Corp) is chemical compound 5-Bromo-5-Nitro-1,3-Dioxane. Its use on goods without license from Cognis is strictly prohibited.

* Formula: C₄H₆BrNO₄
* Synonyms:
** 5-Brom-5-Nitro-1,3-Dioxan
** 5-Bromo-5-nitro-m-Dioxan or 5-Bromo-5-nitro-m-Dioxane
** 1,3-Dioxane, 5-Bromo-5-Nitro-
** BRONIDOX L5
** BRONIDOX L
* Molecular weight: 212.06.

* Color:
** white crystalline powder
** colourless, transparent liquid in 1,2-propylene glycol
* Melting point: 60 °C [http://www.chemicalland21.com/lifescience/phar/5-BROMO-5-NITRO-1,3-DIOXANE.htm] or 58.5-62°C [http://www.furrental.com/pages/fj/bronidox.pdf]
* Light sensitive.
* Solubility: insoluble in water
* pH: 6-7
* Stable under normal conditions
* Non reactive with enzyme/substrate in assays but causes inhibition of enzyme activity n Bacteria [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3082729&dopt=Abstract]
* BRONIDOX L5 is corrosive on metals [http://www.products.cognis.com/COGNIS/prodleaf.nsf/(SBU_Catalog)/FFAD30C61B67EFEB41256B4100427DD1/$File/BRONIDOX_r_L_5_E.pdf]
* ??? "Incompatibilities: strong oxidizing agents" ??? [http://www.chemicon.com/webfiles/MSDS/ECM711msds.pdf]

* CAS Number: 30007-47-7
* EINECS Number: 250-001-7

Used as

* Stabilizer
* Surfactant
* It is used in immunology for preserving antibodies and antisera in 0.1 - 0.5% concentration. It is used as preservative to avoid use of sodium azide.
* Bactericide. Very effective against yeast and fungi.
* used in cosmetics since the mid-1970s as preservative for shampoos, foam bath, etc. Maximum concentration is 0.1 %.

Safety

* Harmful
* Harmful if swallowed R22
* Toxic - tremor, convulsions, excitement
* Irritating to skin R38 - dermatitis
* wear suitable protective clothing S36
* relatively non-toxic to mammals
* some users do not recommend use in preparations destined for in vivo or tissue culture work [http://www.totalreproduction.com/products/specs/Bronidox.html]

* Combustion products: carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen bromide gas, sulfur oxides, hydrogen chloride gas [http://www.chemicon.com/webfiles/MSDS/ECM711msds.pdf]

Toxicology

according to FSASAX
* Oral:
** LD_{50, mouse, oral} 590 mg/kg 24 hours
** LD_{50, rat, oral} 455 mg/kg 24 hours

** LD_{50, rat, ipr.} 31 mg/kg 24 hours

* Skin:
** LD_{50, mouse, skin} 2500 µg/24 hours
** LD_{50, rat, skin} 2500 µg/24 hours

References

* http://www.chemicon.com/webfiles/MSDS/ECM711msds.pdf (Safety data sheet and first aid)
* http://www.chemicalland21.com/lifescience/phar/5-BROMO-5-NITRO-1,3-DIOXANE.htm
* http://www.fitzchem.com/mfg_cogniscare.shtml
* http://www.totalreproduction.com/products/specs/Bronidox.html
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3082729&dopt=Abstract Mode of action of the antimicrobial compound 5-bromo-5-nitro-1,3-dioxane (bronidox)]
* http://www.labodia.com/en/intrinsic_factor/material_safety_data_sheet.pdf

See also

* Bronopol = 2-Bromo-2-nitropropane-1,3-diol

External links