AD-36

Taxobox | color=violet
virus_group = i
familia = "Adenoviridae"
genus = "Mastadenovirus"
species = "Human adenovirus D" (HAdV-D)
serotype = Human adenovirus 36 (HAdV-36)

Human adenovirus 36 (HAdV-36) or AD-36 is one of 51 types of adenoviruses known to infect humans. It was first shown to be associated with obesity in chickens by Dr. Nikhil Dhurandhar.cite journal | first=N V | last=Dhurandhar | coauthors=B A Israel, J M Kolesar, G F Mayhew, M E Cook, R L Atkinson | title=Increased adiposity in animals due to a human virus | year=2000 | journal=International Journal of Obesity | volume=24 | pages=989–996 | doi=10.1038/sj.ijo.0801319] cite journal | last=Whigham | first=Leah D. | coauthors=Barbara A. Israel, and Richard L. Atkinson | title=Adipogenic potential of multiple human adenoviruses in vivo and in vitro in animals | journal=Am J Physiol Regul Integr Comp Physiol | volume=290 | pages=R190–R194 | year=2006]

There has been a positive correlation between body fat and the presence of AD-36 antibodies in the blood (International Journal of Obesity vol29 pages 281-286). Previous research showed that chicken or mice injected with similar types of viruses show a statistically significant weight gain.

To date, AD-36 is the only human adenovirus that has been linked with human obesity, present in 30% of obese humans and 11% of nonobese humans.cite journal |author=Atkinson RL |title=Viruses as an etiology of obesity |journal=Mayo Clin. Proc. |volume=82 |issue=10 |pages=1192–8 |year=2007 |pmid=17908526 |doi=] AD-36 also causes obesity in chickens, mice, rats, and monkeys.

AD-36 infection can induce cellular differentiation of 3T3-L1 preadipocytes and stem cells derived from human adipose tissue.cite journal |author=Rogers PM, Fusinski KA, Rathod MA, "et al" |title=Human adenovirus Ad-36 induces adipogenesis via its E4 orf-1 gene |journal=Int J Obes (Lond) |volume= 32|issue= |pages=397|year=2007 |pmid=17984979 |doi=10.1038/sj.ijo.0803748]

References

External links

* [http://www.webmd.com/diet/news/20040805/fat-virus-could-obesity-be-contagious "The Fat Virus: Could Obesity Be Contagious?"] at WebMD
* [http://news.bbc.co.uk/1/hi/health/854584.stm "Can a virus make you fat?"] at BBC News
* [http://www.scienceblog.com/cms/contagious_obesity_identifying_the_human_adenoviruses_that_may_make_us_fat_9901 "Contagious obesity? Identifying the human adenoviruses that may make us fat"] at Science Blog
* [http://www.biologynews.net/archives/2007/08/20/common_virus_may_contribute_to_obesity_in_some_people_new_study_shows.html "Common virus may contribute to obesity in some people, new study shows"] at Biology News Net