- Bordetella pertussis
color = lightgrey
name = "Bordetella pertussis"
image_width = 240px
regnum = Bacteria
genus = "
species = "B. pertussis"
binomial = "Bordetella pertussis"
binomial_authority = (Bergey "et al." 1923)
"Bordetella pertussis" is a
Gram-negative, aerobic coccobacillusof the genus " Bordetella", and the causative agent of pertussisor whooping cough. Unlike "B. bronchiseptica", "B. pertussis" is non- motile.
There does not appear to be a
zoonoticreservoir for "B. pertussis"—humans are its only host.
The bacterium is spread by coughing and by nasal drops. The incubation period is 7-14 days.
Pertussis(or Whooping Cough), is an infection of the respiratory system and characterized by a “whooping” sound when the person breathes in. In the US it killed 5,000 to 10,000 people per year before a vaccine was available. Vaccinationhas transformed this and between 1985-88 fewer than 100 children died from pertussis. Worldwide in 2000, according to the WHO, around 39 million people were infected annually and about 297,000 died. A graph is available showing the dramatic effect of introducing [http://www.hpa.org.uk/infections/topics_az/whoopingcough/gen_info.htm vaccination in England] .
The infection occurs most with children under the age of one when they are immunized or children with faded
immunity, normally around the age 11 through 18. The signs and symptoms are similar to a common cold: runny nose, sneezing, mild cough, and low-grade fever. After a spell, they might make a “whooping” sound when breathing in or vomit. Adults have milder symptoms, like prolonged coughing without the “whoop.” The patient becomes most contagious during the catarrhalstage of infection, normally 2 weeks after the coughing begins. It may become airborne when the person coughs, sneezes, or laughs. Pertussis vaccineis part of the DTaP ( diphtheria, tetanus, acellular pertussis) immunization. The paroxysmalcough precedes a crowing inspiratory sound characteristic of pertussis. (Infants less than 6 months may not have the typical whoop.) A coughing spell may last a minute or more, producing cyanosis, apnoeaand seizures. A prolonged cough may be irritating and sometimes a disabling cough may go undiagnosed in adults for many months.
"Bordetella pertussis" also produces a lymphocytosis-promoting factor, which causes a decrease in the entry of lymphocytes into lymph nodes. This can lead to a condition known as lymphocytosis, with a complete
lymphocytecount over of 4000/μL in adults or over 8000/μL in children.
A nasopharyngeal swab is sent to the
bacteriologylaboratory for Gram stain(Gram negative, coccobacilli, no arrangement), growth on Bordet-Gengou agaror BCYEplate with added cephalosporinto select for the organism, which shows mercury-drop colonies.
The organism is
oxidasepositive, but urease, nitrase, and citratenegative. It is also non-motile.
* [http://www.who.int/immunization/topics/pertussis/en/index1.html Pertussis] Information from the World Health Organisation
* [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.chapter.1684 "Bordetella" chapter] in Baron's "Medical Microbiology" (online text at the NCBI bookshelf).
* [http://www.arupconsult.com/Topics/Infectious_Disease/Bacteria/Bordetella_pertussis.html "Bordetella pertussis"] in ARUP Consult — The Physician's Guide to Laboratory Test Selection and Interpretation
* [http://www.hpa.org.uk/infections/topics_az/whoopingcough/gen_info.htm Pertussis] United Kingdom Health Protection Agency.
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