Zinc finger protein

Zinc finger protein

A zinc finger protein is a DNA-binding protein domain comprised of zinc fingers ranging from two in the "Drosophila" regulator ADR1, the more common three in mammalian Sp1 up to nine in TFIIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain.

They have also found use in protein engineering due to their modularity and have prospects as components of tools for use in therapeutic gene modulation [Gommans, W. M., H. J. Haisma and M. G. Rots (2005). [http://www.rug.nl/farmacie/onderzoek/basiseenheden/therapeuticgenemodulation/publicaties/publicaties2004/!find?path=/farmacie/onderzoek/basisEenheden/THErapeuticGeneModulation/publicaties/publicaties2004/2005_6.pdf&params=as=pdf "Engineering zinc finger protein transcription factors: the therapeutic relevance of switching endogenous gene expression on or off at command."] Journal of Molecular Biology 354(3): 507-19.] and zinc finger nucleases. [cite journal | author = Durai S, Mani M, Kandavelou K, Wu J, Porteus M, Chandrasegaran S | title = Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells | journal = Nucleic Acids Res | volume = 33 | issue = 18 | pages = 5978–90 | year = 2005 | pmid = 16251401 | url = http://nar.oxfordjournals.org/cgi/content/full/33/18/5978 | doi = 10.1093/nar/gki912 ]

ee also

*Zinc finger chimera - an exploitation of zinc fingers in protein engineering
*Zinc finger nuclease
*Zinc finger inhibitor
*Zinc finger
*DNA-binding domains

References


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  • Zinc finger protein transcription factor — Zinc finger protein transcription factors or ZFP TFs, consisting of activators and repressors are transcription factors composed of a zinc finger protein domain (ZFP) and any of a variety of transcription factor effector domains which exert their …   Wikipedia

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  • zinc finger protein — any of a class of nucleic acid–binding proteins that also contain one or more zinc binding domains (tandemly repeated, highly conserved stretches of 28 nucleotides). The class is named for the fingerlike secondary and tertiary structures formed …   Medical dictionary

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  • Zinc finger chimera — Zinc finger protein chimera are chimeric proteins composed of a DNA binding zinc finger protein domain and another domain through which the protein exerts its effect. The effector domain may be a transcriptional activator (A) or repressor… …   Wikipedia

  • Zinc finger nuclease — Zinc finger nucleases (ZFNs) are artificial restriction enzymes generated by fusing a zinc finger DNA binding domain to a DNA cleavage domain. Zinc finger domains can be engineered to target desired DNA sequences and this enables zinc finger… …   Wikipedia

  • Zinc finger and BTB domain-containing protein 16 — Zinc finger and BTB domain containing 16, also known as ZBTB16, is a human gene. PBB Summary section title = summary text = This gene is a member of the Krueppel C2H2 type zinc finger protein family and encodes a zinc finger transcription factor… …   Wikipedia

  • zinc finger — n any of a class of proteins that typically possess tandem repeats of fingerlike loops of amino acids with each loop containing a zinc binding site at its base consisting of two molecules of cysteine and two molecules of histidine and that… …   Medical dictionary

  • Zinc finger — A zinc finger is a large superfamily of protein domains that can bind to DNA. A zinc finger consists of two antiparallel beta; strands, and an α helix. The zinc ion is crucial for the stability of this domain type in the absence of the metal ion… …   Wikipedia

  • zinc finger — noun : any of a class of proteins that typically possess tandem repeats of fingerlike loops of amino acids with each loop containing a zinc binding site at its base consisting of two molecules of cysteine and two molecules of histidine and that… …   Useful english dictionary

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