Focal nodular hyperplasia
- Focal nodular hyperplasia
Infobox_Disease
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DiseasesDB = 33467
ICD10 =
ICD9 =
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MedlinePlus =
eMedicineSubj = radio
eMedicineTopic = 286
MeshID = D020518
Focal nodular hyperplasia (FNH) is a benign tumour of the liver (hepatic tumour), which is the second most prevalent tumour of the liver (the first is hepatic hemangioma). It is usually asymptomatic, rarely grows or bleeds, and has no malignant potential. This tumour is often resected because it is difficult to distinguish from hepatic adenoma.
Presentation
Focal nodular hyperplasia's most recognizable gross feature is a central stellate scar seen in 60-70% of cases. Microscopically, a lobular proliferation of bland-appearing hepatocytes with a bile ductular proliferation and malformed vessels within the fibrous scar is the most common pattern. Other patterns include telangiectatic, hyperplastic-adenomatous, and lesions with focal large-cell dysplasia.[Nguyen et al. Focal Nodular Hyperplasia of the Liver: A Comprehensive Pathologic Study of 305 Lesions and Recognition of New Histologic Forms. Am J Surg Path 1999:23(12); 1441-4.] Rarely, these lesions may be multiple or can occur as part of a syndrome with hemangiomas, epithelioid hemangioendothelioma, hepatic adenomas, fibrolamellar hepatocellular carcinoma, vascular malformations of the brain, meningiomas, and/or astrocytomas.]Notes
References
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2010.
Look at other dictionaries:
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nodular hyperplasia of the liver — the presence of a regenerative nodule or nodules in the liver; see focal nodular h. and nodular regenerative h … Medical dictionary
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