Dinoprostone

Dinoprostone

drugbox
IUPAC_name = 7- [3-hydroxy-2-(3-hydroxyoct-1-enyl)- 5-oxo-cyclopentyl] hept-5-enoic acid


CAS_number = 363-24-6
ATC_prefix = G02
ATC_suffix = AD02
ATC_supplemental =
PubChem = 9691
DrugBank = APRD00927
C=20 | H=32 | O=5
molecular_weight = 352.465 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
pregnancy_category =
legal_status =
routes_of_administration = In medicine, dinoprostone, is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour and also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. PGE2 is also the prostaglandin that ultimately induces fever.

It is sold under the trade name of Cervidil (by Forest Laboratories, Inc.), Prostin E2 (by Pfizer Inc.) and Propess (by Ferring Pharmaceuticals), as a vaginal suppository, to prepare the cervix for labour; it is used to induce labour.

The chemical name is (5Z,11(alpha),13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-oic acid.

Like other prostaglandins, dinoprostone can be used as an abortifacient.

It works by binding and activating the prostaglandin E2 receptor.

External links

* [http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682512.html Dinoprostone] - medlineplus.org
* [http://www.frx.com/products/cervidil.aspx Cervidil] - Forest Laboratories, Inc. (the distributor of Cervidil).
* [http://www.pfizer.com/pfizer/download/uspi_prostin.pdf Prostin E2] - pfizer.com
* [http://www.rxlist.com/cgi/generic2/dinoprostone.htm Cervidil/Prostin E2] - RxList.com
* [http://www.birthingnaturally.net/birthplan/intervention/cervidil.html What is Cervidil?] - birthingnaturally.net.
* [http://www.drugs.com/cons/Cervidil.html Cervidil/Prostin E2] - drugs.com


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Look at other dictionaries:

  • dinoprostone — noun A naturally occurring prostaglandin, PGE2, with important effects in labour (softening the cervix and causing uterine contraction), sometimes used as an abortifacient …   Wiktionary

  • dinoprostone — An oxytocic agent used as an abortifacient. SYN: prostaglandin E2. * * * n. a prostaglandin drug used mainly to induce labour. It is administered a vaginal tablet or gel. Trade names: Propess, Prostin E2. * * * di·no·prost·one (di″no… …   Medical dictionary

  • dinoprostone — n. a prostaglandin drug used mainly to induce labour. It is usually administered in a pessary or as a vaginal tablet or gel. Trade names: Propess, Prostin E2 …   The new mediacal dictionary

  • Prostaglandin E2 — This article is about the pharmaceutical agent dinoprostone . For the drug dinoprost , see Prostaglandin F2alpha. Prostaglandin E2 Systematic (IUPAC) name (5Z,11α,13E,15S) 7 [3 hydroxy 2 (3 hydroxyoct 1 enyl) 5 oxo cyclopent …   Wikipedia

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  • Misoprostol — Systematic (IUPAC) name Methyl 7 ((1R,2R,3R) 3 hydroxy 2 ((S,E) 4 hydroxy 4 methyloct 1 enyl) 5 oxocyclopentyl)heptanoate Clinical data …   Wikipedia

  • Prostaglandin F2alpha — This article is about the pharmaceutical agent dinoprost . For the drug dinoprostone , see Prostaglandin E2. Dinoprost Tromethamine Systematic (IUPAC) name (Z) 7 [(1R,2R,3R,5S) 3,5 dihydroxy 2 [(E,3S …   Wikipedia

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  • Prostaglandin — A variety of hormone like substances that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, modulation of inflammation …   Medical dictionary

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