- Shy-Drager syndrome
Name = PAGENAME
DiseasesDB = 12042
ICD10 = ICD10|G|90|3|g|90
ICD9 = ICD9|333.0
MeshID = D012791
Shy-Drager syndrome is a rare, progressively
degenerative diseaseof the autonomic nervous system. It is named after Dr Milton Shy and Dr Glenn Drager, who identified this syndrome in 1960. [WhoNamedIt|synd|875] [cite journal |author=Shy GM, Drager GA |title=A neurological syndrome associated with orthostatic hypotension: a clinical-pathologic study |journal=Arch. Neurol. |volume=2 |issue= |pages=511–27 |year=1960 |pmid=14446364 |doi=]
The American Autonomic Society and the American Academy of Neurology deprecated it as a disease entity in
1996, [cite journal |author= | title=Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy |journal=Neurology |volume=46 |issue=5 |pages=1470 |year=1996 |pmid=8628505 |doi=] and existing cases were redefined as multiple system atrophywith autonomic phenomena. The name "Shy-Drager syndrome" is still used occasionally for multiple system atrophywhen the primary symptoms are autonomic failure.
*Problems with the autonomic nervous system, such as
dysphagia, incontinence, hypotension(specifically orthostatic hypotension), gastroparesis, and erectile dysfunction, among others (see autonomic neuropathy).
*Other nonspecific neurologic symptoms such as
ataxiaand pyramidal symptomsFact|date=December 2007
No definitive treatment currently exists. Medications used for
Parkinson's diseasehave not shown to be useful. Treatments are generally geared to give symptomatic control, especially to maintain adequate blood pressure ( adrenergic agonists, and mineralocorticoidanalogs such as fludrocortisone).Fact|date=December 2007
Johnny Cash(possible misdiagnosisof autonomic neuropathy) Fact|date=January 2008
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