Piperonyl butoxide

Chembox new
Name = Piperonyl butoxide
ImageFile = Piperonyl butoxide.png ImageSize = 200px
ImageName = Piperonyl butoxide
IUPACName = 5- [2-(2-butoxyethoxy)ethoxymethyl] -6-propyl-1,3-benzodioxole
Section1 = Chembox Identifiers
CASNo = 51-03-6
SMILES = CCCCOCCOCCOCC1=CC2=C(C=C1CCC)OCO2
Section2 = Chembox Properties
Formula = C₁₉H₃₀O₅
MolarMass = 338.43 g/mol
Density = 1.05 g/cm³
MeltingPt =
BoilingPt = 155 °C
Section7 = Chembox Hazards
FlashPt = 171 °C

Piperonyl butoxide (PBO) is a pesticide synergist. It does not, by itself have pesticidal properties. However, when added to insecticide mixtures, typically pyrethrin, pyrethroid, and carbamate insecticides, their potency is increased considerably. [ [http://npic.orst.edu/factsheets/pbogen.pdf National Pesticide Information Center - Piperonyl Butoxide General Fact Sheet] ]

Piperonyl butoxide is a potent cytochrome P450 inhibitor. This family of enzymes act as the principal detoxification pathway for many pesticides. Inhibiting the detoxification pathway allows higher unmetabolised systemic concentrations of the active insecticide to remain within the target animal for a longer period.

Piperonyl butoxide is moderately stable, and is a semisynthetic derivative of safrole.

It is debatable whether the substance is oncogenic, mutagenic, or teratogenic in humans. Its acute oral and dermal toxicity in mammals is low, however it is toxic to fish and potentiates rotenone. [ [http://npic.orst.edu/factsheets/pbotech.pdf National Pesticide Information Center - Piperonyl Butoxide Technical Fact Sheet] ]

References