Lobo's disease

Infobox_Disease
Name = PAGENAME

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Caption = Histopathological changes in the skin seen in lobomycosis. Source: CDC.
DiseasesDB = 32590
ICD10 = ICD10|B|48|0|b|35
ICD9 = ICD9|116.2
ICDO =
OMIM =
MedlinePlus =
eMedicineSubj = derm
eMedicineTopic = 832
MeshID =

Lobo's disease, also known as lobomycosiscite journal |author=Talhari C, Oliveira CB, de Souza Santos MN, Ferreira LC, Talhari S |title=Disseminated lobomycosis |journal=Int. J. Dermatol. |volume=47 |issue=6 |pages=582–3 |year=2008 |month=June |pmid=18477148 |doi=10.1111/j.1365-4632.2008.03678.x |url=http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0011-9059&date=2008&volume=47&issue=6&spage=582] or lacaziosis,cite journal |author=Xavier MB, Libonati RM, Unger D, "et al" |title=Macrophage and TGF-beta immunohistochemical expression in Jorge Lobo's disease |journal=Hum. Pathol. |volume=39 |issue=2 |pages=269–74 |year=2008 |month=February |pmid=17959227 |doi=10.1016/j.humpath.2007.06.016 |url=http://linkinghub.elsevier.com/retrieve/pii/S0046-8177(07)00353-X] is a blastomycosis, a fungal infection of the skin caused by "Lacazia loboi" (formerly named "Loboa loboi")cite web | last = Honda | first = Kord | coauthors = Horner, Kyle | title = Lobomycosis | publisher = eMedicine | date = 2006 | url = http://www.emedicine.com/derm/topic832.htm | accessdate = 2007-01-18 ] , and discovered by Brazilian dermatologist Jorge Lobo. Other names which were given to the disease are: keloidal blastomycosis, Amazonian blastomycosis, blastomycoid granuloma, miraip and piraip. These last two names were given by natives of the Amazon and mean "that which burns".

This disease is usually found in humans [cite journal |author=Elsayed S, Kuhn SM, Barber D, Church DL, Adams S, Kasper R |title=Human case of lobomycosis |journal=Emerging Infect. Dis. |volume=10 |issue=4 |pages=715–8 |year=2004 |month=April |pmid=15200867 |doi= |url=http://www.cdc.gov/ncidod/EID/vol10no4/03-0416.htm] and bottle-nosed dolphins.

Presentation

"Lacazia loboi" is characterized by long chains of spherical cells interconnected by tubules. The cells appear to be yeast-like with a diameter of 5 -12 μm. The disease is chronic and is characterized by keloidal nodular lesions occurring on the face, ears, or extremities.

Differential diagnosis

The disease is often misdiagnosed as "Blastomyces dermatitidis" or "Paracoccidiodes brasiliensis" due to its similar morphology.

Regions

The disease is endemic in rural regions in South America and Central America.

Lobo's disease in dolphins

Lesions in dolphins occur on the dorsal fin, head, flukes, and peduncle. In January 2006, a potential epidemic of lobomycosis was reported in dolphins of the Indian River Lagoon in Florida.cite journal |author=Reif JS, Mazzoil MS, McCulloch SD, "et al" |title=Lobomycosis in Atlantic bottlenose dolphins from the Indian River Lagoon, Florida |journal=J. Am. Vet. Med. Assoc. |volume=228 |issue=1 |pages=104–8 |year=2006 |month=January |pmid=16426180 |doi=10.2460/javma.228.1.104 |url=http://avmajournals.avma.org/doi/abs/10.2460/javma.228.1.104?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dncbi.nlm.nih.gov]

References

Further reading

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