- Fifth disease
Infobox_Disease
Name = PAGENAME
Caption = 16 month old with fifth disease
DiseasesDB = 4442
ICD10 = ICD10|B|08|3|b|0
ICD9 = ICD9|057.0
ICDO =
OMIM =
MedlinePlus =
eMedicineSubj = emerg
eMedicineTopic = 378
eMedicine_mult = eMedicine2|derm|136 eMedicine2|ped|192
MeshID =Fifth disease is one of several possible manifestations of infection by
parvovirus B19 .cite journal |author=Weir E |title=Parvovirus B19 infection: fifth disease and more |journal=CMAJ |volume=172 |issue=6 |pages=743 |year=2005 |month=March |pmid=15767606 |pmc=552884 |doi=10.1503/cmaj.045293 |url=http://www.cmaj.ca/cgi/pmidlookup?view=long&pmid=15767606] The disease is also referred to as erythema infectiosum (meaning "infectious redness") and as slapped cheek syndrome, slapcheek, slap face or slapped face. In Japan the disease is called 'apple sickness or ringo-byou' (りんご病)in reference to the symptom of facial redness. The name "fifth disease" derives from its historical classification as the fifth of the classical childhood skin rashes orexanthem s.Symptoms
The bright red cheeks are a defining symptom of the infection in children (hence the name "slapped cheek disease"). Occasionally the rash will extend over the bridge of the nose or around the mouth. In addition to the red cheeks, children often develop a red, lacy
rash on the rest of the body, with the upper arms and legs being the most common locations. The rash can last a couple of days (some cases lasting for several weeks) and may itch. Patients are usually no longer infectious once the rash has appeared.Teenagers and adults may present with a self-limited
arthritis .The
disease is usually mild,cite journal |author=Mankuta D, Bar-Oz B, Koren G |title=Erythema infectiosum (Fifth disease) and pregnancy |journal=Can Fam Physician |volume=45 |issue= |pages=603–5 |year=1999 |month=March |pmid=10099795 |pmc=2328398 |doi= |url=] but in certain risk groups it can have serious consequences:
* In pregnant women, infection in the first trimester has been linked tohydrops fetalis , causingspontaneous abortion
* In people withSickle-cell disease or other forms of chronichemolytic anemia , infection can precipitate an aplastic crisis.Epidemiology
Any age may be affected although it is most common in children aged five to fifteen years.cite web |url=http://www.emedicine.com/emerg/topic378.htm |title=eMedicine - Pediatrics, Fifth Disease or Erythema Infectiosum : Article by Kenneth T Kwon |format= |work= |accessdate=] By the time adulthood is reached about half the population will have become
immune following infection at some time in their past. Outbreaks can arise especially in nurseries and schools .The Rash is typically described as 'Erythema Infectiosum'.References
External links
* [http://www.cdc.gov/ncidod/diseases/parvovirus/B19.htm CDC]
* [http://www.b19virus.com/ Parvovirus Information]
* [http://www.slappedcheek.com/ Slapped Cheek Information]
* [http://www.fifthdisease.org/ www.fifthdisease.org]
* [http://www.nhsdirect.nhs.uk/articles/article.aspx?articleId=424§ionId=1 NHS Direct health encyclopaedia]
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