George Emil Palade

Infobox Scientist
name = George Emil Palade
box_width =


image_size =150px
caption =Dr. Palade won the Nobel Prize in 1974.
birth_date = November 19, 1912
birth_place = Iaşi, Romania
death_date = death date and age|2008|10|8|1912|11|19
death_place =
residence = |citizenship = United States
nationality = Romanian
ethnicity =
field = cell biologist
work_institutions =
alma_mater = Carol Davila School of Medicine
doctoral_advisor =
doctoral_students =
known_for = Rough ER
author_abbrev_bot =|author_abbrev_zoo =
influences =
influenced =
prizes = 1974 Nobel Prize in Physiology or Medicine
religion = |footnotes = |

George Emil Palade (November 19, 1912 – October 8, 2008) was a highly regarded Romanian cell biologist. In 1974, he shared the Nobel Prize in Physiology or Medicine with Albert Claude and Christian de Duve, for his discoveries concerning the structure and function of organelles in biological cells.

Dr. Palade also received the U.S. National Medal of Science in Biological Sciences for "pioneering discoveries of a host of fundamental, highly organized structures in living cells..." in 1986,( [http://upload.wikimedia.org/wikipedia/commons/9/9a/National_Medal_of_Science.gifNational Medal of Science] ), and was previously elected a Member of the National Academy of Science in 1961.

Biography

George E. Palade received his M.D. in 1940 from the Carol Davila School of Medicine of the University of Bucharest, Romania. He was a member of the faculty of that famous school until 1945 when he went to the United States for postdoctoral studies. There, he joined Prof. Albert Claude at the Rockefeller Institute for Medical Research. cn

In 1952, Dr.Palade became a naturalized citizen of the United States. He was a Professor at the Rockefeller Institute (1958-1973), Yale University Medical School (1973-1990), and University of California, San Diego (1990-2008). At UCSD, Dr. Palade was Professor of Medicine in Residence (Emeritus) in theDepartment of Cellular & Molecular Medicine, as well as a Dean for Scientific Affairs (Emeritus), in the School of Medicine at La Jolla, California. [ [http://cmm.ucsd.edu/palade/ Professor George E. Palade] - web page atthe University of California at San Diego, School of medicine] In 1970, he was awarded [ [http://www.cumc.columbia.edu/horwitz/ The Horowitz Prize] ] the Louisa Gross Horwitz Prize from Columbia University together with Renato Dulbecco co-winner of 1974 Nobel Prize in Physiology or Medicine "for discoveries concerning the functional organization of the cell that were seminal events in the development of modern cell biology".", [ [http://nobelprize.org/nobel_prizes/medicine/laureates/1974/ "The 1974 Nobel Prize for Medicine"] ] related to his previous research carried out at the Rockefeller Institute for Medical Research [http://www.rockefeller.edu/nobel.html] . His Nobel lecture, delivered on December 12, 1974, was entitled: "Intracellular Aspects of the Process of Protein Secretion" [ [http://nobelprize.org/nobel_prizes/medicine/laureates/1974/palade-lecture.html Nobel lecture] ] , published in 1992 by the Nobel Prize Foundation [ [http://nobelprize.org/nobel_prizes/medicine/laureates/1974/palade-lecture.pdf The Nobel Prize Lecture of George E. Palade] (Pdf 3.78 MB), (1974) The Nobel Foundation, ISBN 981-02-0791-3] , [ [http://nobelprize.org/nobelfoundation/publications/lectures/WSC/physio-71-80.html Nobel Lectures in Physiology or Medicine] ] At the Rockefeller Institute for Medical Research, Dr. Palade used electron microscopy to study the internal organization of such cell structures as mitochondria, chloroplasts, the Golgi apparatus, and others. His most important discovery was made while using an experimental strategy known as a pulse-chase analysis. In the experiment Palade and his colleagues were able to confirm an existing hypothesis that a secretory pathway exists and that the Rough ER and the Golgi apparatus function together.

He focused on Weibel-Palade bodies (a storage organelle unique to the endothelium, containing von Willebrand factor and various proteins) which he described together with the Swiss anatomist Ewald R. Weibel [Weibel ER, Palade GE. "New cytoplasmic components in arterial endothelia". "J. Cell. Biol." 1964, 23: 101-112). http://www.jcb.org/cgi/content/abstract/23/1/101]

Palade was married to Marilyn Farquhar, a cell biologist at the University of California, San Diego.

Inline notes and references

ources

*cite journal
quotes = yes
year=2007|month=
title=Tribute to Professor George E. Palade
journal=J. Cell. Mol. Med.
volume=11
issue=1
pages=2–3
publisher= |location = Romania| issn = 1582-1838| pmid = 17367496
doi = 10.1111/j.1582-4934.2007.00018.x
bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote =
author = Palade, George E.
*cite journal
quotes = yes
last=Singer
first=Manfred V
authorlink=
year=2003|month=
title=Legacy of a distinguished scientist: George E. Palade
journal=Pancreatology
volume=3
issue=6
pages=518–9
publisher= |location = Switzerland| issn = 1424-3903| pmid = 14730177
doi = 10.1159/000076328
bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote =
*cite journal
quotes = yes
last=Haulică
first=I
authorlink=
year=|month=
title= [Professor doctor George Emil Palade at 90 years of age]
journal=Revista medico-chirurgicală a Societăţii de Medici şi Naturalişti din Iaşi
volume=107
issue=2
pages=223–5
publisher= |location = Romania| issn = 0300-8738| pmid = 12638263
bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote =
*cite journal
quotes = yes
last=Tartakoff
first=Alan M
authorlink=
year=2002|month=Nov.
title=George Emil Palade: charismatic virtuoso of cell biology
journal=Nat. Rev. Mol. Cell Biol.
volume=3
issue=11
pages=871–6
publisher= |location = England| issn = 1471-0072| pmid = 12415304
doi = 10.1038/nrm953
bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote =
*cite journal
quotes = yes
last=Motta
first=P M
authorlink=
year=2001|month=
title=George Emil Palade and Don Wayne Fawcett and the development of modern anatomy, histology and contemporary cell biology
journal=Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia
volume=106
issue=2 Suppl 1
pages=XXI–XXXVIII
publisher= |location = Italy| issn = 1122-6714| pmid = 11730003
bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote =
*cite journal
quotes = yes
last=Farquhar
first=M G
authorlink=
coauthors=Wissig S L, Palade G E
year=1999|month=Dec.
title=Glomerular permeability I. Ferritin transfer across the normal glomerular capillary wall. 1961
journal=J. Am. Soc. Nephrol.
volume=10
issue=12
pages=2645–62
publisher= |location = UNITED STATES| issn = 1046-6673| pmid = 10589706
bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote =
*cite journal
quotes = yes
last=Raju
first=T N
authorlink=
year=1999|month=Oct.
title=The Nobel chronicles. 1974: Albert Claude (1899-1983), George Emil Palade (b 1912), and Christian Réne de Duve (b 1917)
journal=Lancet
volume=354
issue=9185
pages=1219
publisher= |location = ENGLAND| issn = 0140-6736| pmid = 10513750
bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote =
doi = 10.1016/S0140-6736(05)75433-7
*cite journal
quotes = yes
last=Sabatini
first=D D
authorlink=
year=1999|month=Oct.
title=George E. Palade: charting the secretory pathway
journal=Trends Cell Biol.
volume=9
issue=10
pages=413–7
publisher= |location = ENGLAND| issn = 0962-8924| pmid = 10481180
bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote =
doi = 10.1016/S0962-8924(99)01633-5
*cite journal
quotes = yes
last=Motta
first=P M
authorlink=
year=|month=
title=George Emil Palade and Don Wayne Fawcett and the development of modern anatomy, histology and contemporary cell biology
journal=Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia
volume=103
issue=2
pages=65–81
publisher= |location = ITALY| issn = 1122-6714| pmid = 9719773
bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote =
*cite journal
quotes = yes
last=Porter
first=K R
authorlink=
year=1983|month=Jul.
title=An informal tribute to George E. Palade
journal=J. Cell Biol.
volume=97
issue=1
pages=D3–7
publisher= |location = UNITED STATES| issn = 0021-9525| pmid = 6345553
bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote =
*cite journal
quotes = yes
last=Tashiro
first=Y
authorlink=
year=1975|month=Jan.
title= [Accomplishment of Drs. Albert Calude and George E. Palade and the birth of cell biology]
journal=Tanpakushitsu Kakusan Koso
volume=20
issue=1
pages=74–6
publisher= |location = JAPAN| issn = 0039-9450| pmid = 1094498
bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote =
*cite journal
quotes = yes
last=Magner
first=J W
authorlink=
coauthors=Ritchie E H, Cahill S C
year=1975|month=Jan.
title=Current medical literature
journal=Journal of the Indian Medical Association
volume=64
issue=1
pages=20–2
publisher= |location = INDIA| issn = 0019-5847| pmid = 1094070
bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote =
*cite journal
quotes = yes
year=1970|month=
title=George E. Palade
journal=Triangle; the Sandoz journal of medical science
volume=9
issue=6
pages=229–30
publisher= |location = SWITZERLAND| issn = 0041-2597| pmid = 4927031
bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote =

External links

* [http://www.nobel.se/medicine/laureates/1974/palade-autobio.html Autobiography written in 1974 for the Nobel Prize]
* [http://cmm.ucsd.edu/palade/ Professor Palade's webpage at University of California, San Diego]
* [http://cellimages.ascb.org/u?/p4041coll1,110 George Palade biography Image & Video Library]
* [http://www.cumc.columbia.edu/horwitz/ The Official Site of Louisa Gross Horwitz Prize]