Excision repair

Excision repair

Excision repair is a term applied to several DNA repair mechanisms.

Excision repair mechanisms that remove the damaged nucleotide replacing it with an undamaged nucleotide complementary to the nucleotide in the undamaged DNA strand. These include:
*Base excision repair (BER), which repairs damage due to a single nucleotide caused by oxidation, alkylation, hydrolysis, or deamination;
*Nucleotide excision repair (NER), which repairs damage affecting 2−30 nucleotide-length strands. These include bulky, helix distorting damage, such as thymine dimerization and other types of cyclobutyl dimerization caused by UV light as well as single-strand breaks. A specialized form of NER known as Transcription-Coupled Repair (TCR) deploys high-priority NER repair enzymes to genes that are being actively transcribed;
*Mismatch repair (MMR), which corrects errors of DNA replication and recombination that result in mispaired nucleotides.


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  • excision repair — dark repair (см.). (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • excision repair — noun An enzymatic DNA repair process in which a mismatching DNA sequence is removed, the gap being filled by synthesis of a new sequence complementary to the remaining strand • • • Main Entry: ↑excise …   Useful english dictionary

  • excision repair — excision repair. См. эксцизионная репарация. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Excision repair cross-complementing — (ERCC) is a set of proteins which are involved in DNA repair.The genes include: Gene|ERCC1, ERCC2 , Gene|ERCC3, Gene|ERCC4, Gene|ERCC5, Gene|ERCC6, and Gene|ERCC8.Members 6 and 8 are associated with Cockayne syndrome …   Wikipedia

  • excision repair — Mechanism for the repair of environmental damage to one strand of DNA (loss of purines due to thermal fluctuations, formation of pyrimidine dimers by UV irradiation). The site of damage is recognized, excised by an endonuclease, the correct… …   Dictionary of molecular biology

  • excision repair — DNA repair processes that involve the removal of a damaged or incorrect segment of one strand of double stranded DNA and its replacement by the synthesis of a new segment using the complementary strand of DNA as template …   Glossary of Biotechnology

  • Nucleotide excision repair — Diagram[1] Nucleotide excision repair is a DNA repair mechanism.[2] DNA constantly requires r …   Wikipedia

  • Base excision repair — (BER) is a cellular mechanism that repairs damaged DNA throughout the cell cycle. Repairing DNA sequence errors is necessary so that mutations are not propagated or to remove lesions that may lead to breaks in the DNA during replication.Single… …   Wikipedia

  • Base excision repair — Réparation par excision de base La réparation par excision de base (ou BER pour Base excision repair en anglais) est un mécanisme de réparation d un dommage au niveau d’une base individuelle de l’ADN. Un tel dommage est réparé par simple… …   Wikipédia en Français

  • nucleotide excision repair — (NER) repair of bulky lesions introduced into DNA by damage, such as that induced by ultraviolet light; at least 30 proteins are involved and the process consists of recognition of the lesion, strand separation at the site, single strand incision …   Medical dictionary

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